INT180142

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.19
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (SIRT2) cytoskeleton (SIRT2) cell cycle (SIRT2)
cell division (SIRT2) transcription factor binding (SIRT2) cytoplasm (SIRT2)
Anatomy Link Frequency
grid 1
brain 1
SIRT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 98.64 Very High Very High Very High
palliative 65 98.40 Very High Very High Very High
addiction 2 81.92 Quite High
cerebral cortex 15 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
noradrenaline 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 17 98.64 Very High Very High Very High
Death 5 88.72 High High
Anxiety Disorder 3 24.32 Low Low
Rheumatoid Arthritis 25 21.36 Low Low
Unconsciousness 29 5.00 Very Low Very Low Very Low
Coma 22 5.00 Very Low Very Low Very Low
Convulsion 20 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 8 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
And indeed, the only way to do so is to physically split the brain in two to prevent information integration between the two hemispheres.
Negative_regulation (prevent) of information in brain
1) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Specifically, we define the effective information between A and B as EI(A?
Negative_regulation (define) of effective information
2) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Information is classically defined as
                   reduction of uncertainty. 
Negative_regulation (reduction) of Information
3) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0 Pain Relevance 0
We show that the amount
                   of integrated information generated by a complex can be interpreted as the
                   “height” of the quale. 
Negative_regulation (interpreted) of information
4) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0 Pain Relevance 0
A cluster analysis of aspects of palliative care satisfaction in the literature resulted in four dominant sub-domains emerging: availability of care, information giving, physical care (including pain and symptom management), and psychosocial care [82].
Negative_regulation (availability) of information associated with pain and palliative
5) Confidence 0.03 Published 2010 Journal BMC Palliat Care Section Body Doc Link PMC2876145 Disease Relevance 0.19 Pain Relevance 0.41
The a priori repertoire is smaller than in Figure 1, and effective information is reduced to 2 bits.
Negative_regulation (reduced) of effective information
6) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
It can be seen from the 4 panels in the figure that inactive states – with no elements firing – are typically associated with low values of integrated information.
Negative_regulation (values) of information
7) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
On the other hand, integrated information also decreases dramatically when the system is in a hyperactive state, with all elements firing.
Negative_regulation (decreases) of information
8) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Note that, if we attempt to address this problem by adding horizontal connections between elements, so that the components are integrated within, we introduce a second problem: the horizontal couplings shrink the a posteriori repertoires of the components, reducing effective information between them.
Negative_regulation (reducing) of effective information
9) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
The inefficiency increases with the size of the grid; for example an XOR-grid of a million elements is needed to generate 1000 bits of integrated information. ?
Negative_regulation (bits) of information in grid
10) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0

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