INT180144

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 57
Total Number 57
Disease Relevance 1.29
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (SIRT2) cytoskeleton (SIRT2) cell cycle (SIRT2)
cell division (SIRT2) transcription factor binding (SIRT2) cytoplasm (SIRT2)
Anatomy Link Frequency
grid 2
brain 2
joint 1
neurons 1
external 1
SIRT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 44 82.36 Quite High
cerebral cortex 104 80.76 Quite High
Thalamus 16 74.12 Quite High
Anterior cingulate 16 67.56 Quite High
Pain 93 51.52 Quite High
imagery 32 38.56 Quite Low
medulla 64 5.00 Very Low Very Low Very Low
Spinal cord 16 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
Dopamine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 40 99.72 Very High Very High Very High
Rheumatoid Arthritis 140 98.82 Very High Very High Very High
Convulsion 132 96.92 Very High Very High Very High
Coma 152 83.28 Quite High
Dissociative Disorders 16 77.92 Quite High
Unconsciousness 204 75.84 Quite High
Cognitive Disorder 60 64.36 Quite High
Pain 92 51.52 Quite High
Anxiety Disorder 16 44.56 Quite Low
Confusion 16 18.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the time scale of neurophysiological interactions needed to integrate information among distant cortical regions appears to be consistent with that required by psychophysical observations (microgenesis), by stimulation experiments, and by recording experiments.



information Binding (integrate) of
1) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
is the amount of effective information that can be exchanged across the minimum information bipartition of a complex.
minimum information bipartition Binding (complex) of
2) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0.05 Pain Relevance 0.05
Moreover, it should be possible to design the quality of their conscious experience by appropriately structuring their effective information matrix.
effective information Binding (matrix) of
3) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
That is, the way information can be integrated within a complex determines not only how much consciousness is has, but also what kind of consciousness.
information Binding (integrated) of
4) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
In addition to neuroanatomical factors, neurophysiological factors are also important in determining to what extent a given neural structure can integrate information.
information Binding (integrate) of in neural
5) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0.08 Pain Relevance 0
It takes its start from phenomenology and, by making a critical use of thought experiments, it argues that subjective experience is one and the same thing as a system's capacity to integrate information.
information Binding (integrate) of
6) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
This is because, due to the multitude of causal interactions among the elements of your brain, the state of each element is causally dependent on that of other elements, which is why information can be integrated among them.
information Binding (integrated) of in brain
7) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Instead, the elements of the main complex and of the connected cycles form a joint complex that can only integrate the limited amount of information exchanged within each cycle.
information Binding (integrate) of in joint
8) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0.14 Pain Relevance 0.07
It follows that any physical system has subjective experience to the extent that it is capable of integrating information, irrespective of what it is made of.
information Binding (integrating) of
9) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
This is because, due to the absence of interactions among the photodiodes within the sensory chip, the state of each element is causally independent of that of the other elements, and no information can be integrated among them.
information Binding (integrated) of
10) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Similarly, a subset can integrate little information if there is a way to partition it in two parts A and B such that EI(A B) is low: the effective information across that bipartition is the limiting factor on the subset's information integration capacity.
information Binding (integrate) of
11) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
According to the theory, just as the quantity of consciousness associated with a complex is determined by the amount of information that can be integrated among its elements, the quality of its consciousness is determined by the informational relationships that causally link its elements [13].
information Binding (integrated) of
12) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0.03
The minimum information bipartition MIBA B of subset S – its 'weakest link' – is its bipartition for which the normalized effective information reaches a minimum, corresponding to min{EI(A B)/Hmax(A B)}.
minimum information bipartition Binding (bipartition) of
13) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
According to the theory, the reason lies with the organization of cerebellar connections, which is radically different from that of the thalamocortical system and is not well suited to information integration.
information Binding (suited) of
14) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0.04
According to the theory, the key difference between you and the camera has to do with information integration.
information Binding (do) of
15) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
If consciousness corresponds to the capacity to integrate information, then a physical system should be able to generate consciousness to the extent that it has a large repertoire of available states (information), yet it cannot be decomposed into a collection of causally independent subsystems (integration).
information Binding (integrate) of
16) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Today, the challenge will be to present a social-geographical map, indicating in various domains and regions how human genomics information is used, or bound to be used, and what infrastructures are emerging that may allow us to govern this process in such a manner that individuals may position themselves as the subjects, rather than as the objects, as the performers rather than the targets, of this consequential development.



information Binding (bound) of
17) Confidence 0.04 Published 2009 Journal Med Stud Section Body Doc Link PMC2837237 Disease Relevance 0 Pain Relevance 0
Considering the information generated by a complex of elements in terms of the
                   shape they specify in Q has some implications for the way we interpret
                   neurophysiologic data. 
information Binding (complex) of
18) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0 Pain Relevance 0
Indeed, there exists no complex corresponding to the double couple
                       – as a whole, such a system does not generate any quantity of
                       consciousness (measured by integrated information, ?)
information Binding (integrated) of
19) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0 Pain Relevance 0
A measure of integrated information, called phi (?)
information Binding (integrated) of
20) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0.08 Pain Relevance 0

General Comments

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