INT180163

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2009
Negated 1
Speculated 3
Reported most in Body
Documents 49
Total Number 56
Disease Relevance 31.96
Pain Relevance 9.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
B cells 3
node 2
macrophages 1
dendritic cells 1
bone marrow 1
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1080 100.00 Very High Very High Very High
Osteoarthritis 238 100.00 Very High Very High Very High
sodium channel 78 98.96 Very High Very High Very High
Inflammation 548 97.60 Very High Very High Very High
methotrexate 224 95.16 Very High Very High Very High
metalloproteinase 267 94.64 High High
chemokine 192 94.00 High High
cytokine 333 93.36 High High
cva 17 91.88 High High
gABA 4 91.76 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1080 100.00 Very High Very High Very High
Osteoarthritis 238 100.00 Very High Very High Very High
Skin Infection 56 100.00 Very High Very High Very High
Infection 1935 99.98 Very High Very High Very High
Primary Effusion Lymphoma 25 99.84 Very High Very High Very High
Adhesions 83 99.78 Very High Very High Very High
Injury 184 99.62 Very High Very High Very High
Epstein-barr Virus 325 99.16 Very High Very High Very High
Contagious Ecthyma 75 99.06 Very High Very High Very High
Hemophilus Infection 89 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that sodium channels are not randomly delivered to the axolemma but are targeted to the nascent node independently of either Nfasc186 or Nfasc155, although one or both of these proteins is clearly required to stabilize the nascent node.
Positive_regulation (targeted) of Nfasc155 in node associated with sodium channel
1) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.26
This indicates that sodium channels are not randomly delivered to the axolemma but are targeted to the nascent node independently of either Nfasc186 or Nfasc155, although one or both of these proteins is clearly required to stabilize the nascent node.
Positive_regulation (targeted) of Nfasc186 in node associated with sodium channel
2) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.26
Histological alterations and granulocytes infiltration in kidney were assessed alongised PMN accumulation, activation of NF-??
Positive_regulation (activation) of NF in granulocytes
3) Confidence 0.38 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2430988 Disease Relevance 0.68 Pain Relevance 0
Results: Treatment of thermally injured mice with CORM-2 significantly attenuated PMN accumulation and prevented activation of NF-??
Positive_regulation (activation) of NF
4) Confidence 0.27 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2430988 Disease Relevance 0.64 Pain Relevance 0
Thermal injury has been known to induce hepatic NF-?
Positive_regulation (induce) of NF associated with injury
5) Confidence 0.24 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.37 Pain Relevance 0.27
Up-regulation of FLIP, caspase-8 inhibitor, enhanced NF-?
Positive_regulation (enhanced) of NF
6) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.95 Pain Relevance 0.09
HV68 homolog of EBV gp350, gp150, is involved in the initial activation of NF-?
Positive_regulation (activation) of NF associated with epstein-barr virus
7) Confidence 0.16 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.57 Pain Relevance 0.06
M-expressing viruses strongly inhibited MEKK1 activation of the NF-?
Positive_regulation (activation) of NF
8) Confidence 0.14 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.62 Pain Relevance 0
HV68-infected mice [85], raising the possibility that vGPCR mediated induction of NF-?
Positive_regulation (induction) of NF
9) Confidence 0.14 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.56 Pain Relevance 0.19
In an independent experiment, the synergistic induction of the NF-?
Positive_regulation (induction) of NF
10) Confidence 0.14 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.54 Pain Relevance 0
This indicates that activation of NF-?
Positive_regulation (activation) of NF
11) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.05 Pain Relevance 0
Engagement of primary B cells with CD40L leads to the activation of NF-?
Positive_regulation (activation) of NF in B cells
12) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.44 Pain Relevance 0.08
B activation for establishment of latency in vivo, it is possible that initial activation of NF-?
Spec (possible) Positive_regulation (activation) of NF
13) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.64 Pain Relevance 0.08
B (e.g., through virus binding and entry) may serve to promote establishment of a latent infection in the appropriate cellular context prior to expression of latency-associated viral genes that activate NF-?
Positive_regulation (activate) of NF associated with infection
14) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.63 Pain Relevance 0.07
HV68 encodes other, as-yet-unidentified, gene products that modulate the activation of NF-?
Positive_regulation (activation) of NF
15) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.45 Pain Relevance 0.03
M might reflect (i) the utilization of alternative NIK/IKK1-mediated NF-?
Positive_regulation (mediated) of NF
16) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.33 Pain Relevance 0
Taken together, the lack of complementation by Bcl-2 at any time point after infection indicates that NF-?
Positive_regulation (indicates) of NF associated with infection
17) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.29 Pain Relevance 0
M phenotype [88], making it unlikely that gp150 plays a critical role in activating NF-?
Positive_regulation (activating) of NF
18) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.43 Pain Relevance 0
However, the requirement of NF-?
Positive_regulation (requirement) of NF
19) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.21 Pain Relevance 0.09
HV68 and, as such, are not candidates for mediating NF-?
Positive_regulation (mediating) of NF
20) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.65 Pain Relevance 0.24

General Comments

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