INT180183

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 107 100.00 Very High Very High Very High
dexamethasone 63 100.00 Very High Very High Very High
Inflammation 34 92.00 High High
Pain 7 73.48 Quite High
Arthritis 85 72.92 Quite High
diclofenac 1 64.24 Quite High
rheumatoid arthritis 125 61.56 Quite High
metalloproteinase 26 50.00 Quite Low
methotrexate 8 36.84 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 39 93.20 High High
Arthritis 97 92.48 High High
INFLAMMATION 31 90.60 High High
Body Weight 5 74.68 Quite High
Pain 7 73.48 Quite High
Weight Loss 1 61.80 Quite High
Rheumatoid Arthritis 125 61.56 Quite High
Apoptosis 72 55.76 Quite High
Glioblastoma 47 50.00 Quite Low
Arthropathy 8 15.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells pretreated with DXM and then treated with TMZ showed a significant decrease in the generation of 145 kD SBDP, indicating an inhibitory effect of DXM on TMZ mediated increase in calpain activity (panel C, Fig. 5).
Regulation (effect) of Positive_regulation (increase) of Fig associated with dexamethasone
1) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.06 Pain Relevance 0.33
Mixtures of TIMP-2 with IgG fractions had variable effect on MMP9 activation (Fig. 4).
Regulation (effect) of Positive_regulation (activation) of Fig
2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.11 Pain Relevance 0.06
Overall, the increases in adalimumab ACR20, ACR50, and ACR70 response rates were time dependent (Fig. 2).
Regulation (dependent) of Positive_regulation (increases) of Fig associated with adalimumab
3) Confidence 0.05 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.12 Pain Relevance 0.35
The production of the serum protein albumin is affected by the induction of acute-phase proteins such as CRP (Fig. 2, top panel).
Regulation (affected) of Positive_regulation (induction) of Fig
4) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.18 Pain Relevance 0.23

General Comments

This test has worked.

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