INT180184

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.75
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MGMT) methyltransferase activity (MGMT) nucleus (MGMT)
DNA binding (MGMT)
Anatomy Link Frequency
GBM 2
MGMT (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 28 95.28 Very High Very High Very High
dexamethasone 134 66.00 Quite High
positron emission tomography 4 44.68 Quite Low
Inflammation 12 31.60 Quite Low
vincristine 2 27.80 Quite Low
methotrexate 2 27.28 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 294 100.00 Very High Very High Very High
Glioblastoma 152 97.20 Very High Very High Very High
Malignant Neoplastic Disease 24 84.68 Quite High
Cancer 78 83.84 Quite High
Apoptosis 144 81.92 Quite High
Toxicity 6 80.56 Quite High
Death 26 75.04 Quite High
Recurrence 6 68.64 Quite High
Brain Tumor 40 61.84 Quite High
Obesity 8 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the patient in this study expressed hypermethylation of the MGMT gene promoter, which enhances the therapeutic action of temozolomide and is prognostic for increased survival [26], no prior cases of rapid GBM regression have been reported in patients with the MGMT hypermethylation phenotype to our knowledge.
Positive_regulation (hypermethylation) of Gene_expression (expressed) of MGMT in GBM associated with glioblastoma
1) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.78 Pain Relevance 0.13
Continuous temozolomide administration depletes O6-methylguanine-DNA methyltransferase, which is required for repairing DNA damage.
Positive_regulation (methyltransferase) of Gene_expression (methyltransferase) of O6-methylguanine-DNA
2) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.91 Pain Relevance 0.08
However, O6-methylguanine (O6-meG) may be removed by O6-methylguanine methyl transferase (MGMT) [25].
Positive_regulation (transferase) of Gene_expression (transferase) of MGMT
3) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.32 Pain Relevance 0.09
However, O6-methylguanine (O6-meG) may be removed by O6-methylguanine methyl transferase (MGMT) [25].
Positive_regulation (transferase) of Gene_expression (transferase) of O6-methylguanine
4) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.33 Pain Relevance 0.09
MGMT-mediated increase in marking of a lentiviral anti-HIV vector
Positive_regulation (increase) of Gene_expression (vector) of MGMT associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.41 Pain Relevance 0
MGMT-mediated selection of transduced macaque repopulating cells and in vivo tracking of marked cells
Positive_regulation (mediated) of Gene_expression (selection) of MGMT
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0 Pain Relevance 0

General Comments

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