INT180185

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 15.02
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MGMT) methyltransferase activity (MGMT) nucleus (MGMT)
DNA binding (MGMT)
Anatomy Link Frequency
skin 2
arm 1
GBM 1
MGMT (Homo sapiens)
MGMT - P140K (1)
Pain Link Frequency Relevance Heat
Antiemetics 12 97.20 Very High Very High Very High
Analgesic 12 96.68 Very High Very High Very High
imagery 58 96.04 Very High Very High Very High
headache 10 92.28 High High
Pain 45 92.08 High High
COX2 2 84.56 Quite High
Nerve growth factor 12 84.52 Quite High
dexamethasone 138 67.52 Quite High
positron emission tomography 6 59.36 Quite High
methotrexate 3 49.44 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1765 100.00 Very High Very High Very High
Glioblastoma 188 99.98 Very High Very High Very High
Infection 252 99.78 Very High Very High Very High
Cancer 387 99.32 Very High Very High Very High
Immunodeficiency 12 98.80 Very High Very High Very High
Skin Cancer 44 98.76 Very High Very High Very High
Lung Cancer 61 98.44 Very High Very High Very High
Vomiting 18 97.20 Very High Very High Very High
Lymphatic System Cancer 48 96.08 Very High Very High Very High
Glioma 64 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Small studies have suggested that MGMT methylation status may predict improved OS [29], but the small size of these studies and a potential confounding correlation between MGMT methylation and 1p/19q codeletion mandate larger studies.
Gene_expression (methylation) of MGMT
1) Confidence 0.65 Published 2010 Journal Curr Neurol Neurosci Rep Section Body Doc Link PMC2857752 Disease Relevance 0.81 Pain Relevance 0.03
Continuous temozolomide administration depletes O6-methylguanine-DNA methyltransferase, which is required for repairing DNA damage.
Gene_expression (methyltransferase) of O6-methylguanine-DNA
2) Confidence 0.64 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.91 Pain Relevance 0.08
Although the patient in this study expressed hypermethylation of the MGMT gene promoter, which enhances the therapeutic action of temozolomide and is prognostic for increased survival [26], no prior cases of rapid GBM regression have been reported in patients with the MGMT hypermethylation phenotype to our knowledge.
Gene_expression (expressed) of MGMT in GBM associated with glioblastoma
3) Confidence 0.64 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.78 Pain Relevance 0.13
Following incomplete surgical resection, the patient was diagnosed with glioblastoma multiforme expressing hypermethylation of the MGMT gene promoter.


Gene_expression (expressing) of MGMT associated with glioblastoma
4) Confidence 0.57 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2874558 Disease Relevance 0.87 Pain Relevance 0.28
We found that MGMT and DIRAS3 were statistically significantly more highly methylated in adjacent non-tumor than in SQ samples, while for TMEFF2, we observed almost no difference in methylation levels between tumor and non-tumor tissue (Table 1).
Gene_expression (methylated) of MGMT associated with cancer and skin cancer
5) Confidence 0.51 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2483990 Disease Relevance 1.01 Pain Relevance 0
However, O6-methylguanine (O6-meG) may be removed by O6-methylguanine methyl transferase (MGMT) [25].
Gene_expression (transferase) of MGMT
6) Confidence 0.44 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.32 Pain Relevance 0.09
However, O6-methylguanine (O6-meG) may be removed by O6-methylguanine methyl transferase (MGMT) [25].
Gene_expression (transferase) of O6-methylguanine
7) Confidence 0.44 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.33 Pain Relevance 0.09
Thus, the marking level in the control EYFP experimental arm of M05270 closely matched what we observed in macaque M05189, which received the vector that expresses the C46 transgene and MGMT in addition to the EGFP transgene.
Gene_expression (expresses) of MGMT in arm
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.29 Pain Relevance 0
to the C46 transgene and upstream of the MGMT transgene so that the C46 is expressed from SFFV and MGMT is expressed from an IRES to create the resulting vector plasmid pRSC-SC46-IMPGW.
Gene_expression (expressed) of MGMT
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.72 Pain Relevance 0.30
The alkylating agent BCNU is toxic to cells that do not express MGMT, so in the presence of both agents cells that do not express the mutant P140K MGMT are killed resulting in an increase in the percentage of marked EGFP-expressing cells.
Neg (not) Gene_expression (express) of MGMT
10) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.34 Pain Relevance 0
The MGMT protein is expressed in normal human tissues, so in order to enhance selection, a potent inhibitor, O6-benzylguanine (O6BG) is used to inactivate endogenous MGMT.
Gene_expression (expressed) of MGMT
11) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.66 Pain Relevance 0
The natural expression of MGMT is a key in maintaining DNA stability of the DNA structure and repairing DNA alkylation damage. hMSH2 mRNA can repair a variety of DNA damage, including alkyl-base mismatches, insertions or deletions, and structural abnormalities, which lowers the mutation frequency and maintains stability of DNA structure.
Gene_expression (expression) of MGMT associated with congenital anomalies
12) Confidence 0.38 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.15 Pain Relevance 0
They examined the methylation status of the CIMP panel, as well as two additional genes (CDKN2A and CRABP1) and the promoter region of MGMT (O-6-methylguanine-DNA methyltransferase), a gene involved in DNA repair.
Gene_expression (methyltransferase) of O-6-methylguanine-DNA
13) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.66 Pain Relevance 0.04
They examined the methylation status of the CIMP panel, as well as two additional genes (CDKN2A and CRABP1) and the promoter region of MGMT (O-6-methylguanine-DNA methyltransferase), a gene involved in DNA repair.
Gene_expression (methyltransferase) of MGMT
14) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.66 Pain Relevance 0.04
MGMT-mediated selection of transduced macaque repopulating cells and in vivo tracking of marked cells
Gene_expression (selection) of MGMT
15) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0 Pain Relevance 0
Importantly, we show that following engraftment, MGMT selection, and differentiation in vivo, these cells were protected from SHIV infection.
Gene_expression (selection) of MGMT associated with infection
16) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.83 Pain Relevance 0
MGMT-mediated increase in marking of a lentiviral anti-HIV vector
Gene_expression (vector) of MGMT associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.41 Pain Relevance 0
Epigenomics examples: DPD and MGMT
Gene_expression (examples) of MGMT
18) Confidence 0.35 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.45 Pain Relevance 0
Our study also found that As exposure has a profound negative impact on DNA repair, decreasing positive expression for XRCC1, MGMT, and hMSH2 mRNA with the increasing severity of skin lesion in arsenicosis patients (Table 3).
Gene_expression (expression) of MGMT in skin
19) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
High level expression of the C46 fusion inhibitor is required for a potent antiviral effect [35], so we expressed C46 from the strong SFFV promoter and expressed MGMT from an IRES.
Gene_expression (expressed) of MGMT
20) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox