INT180186

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.86
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
Anatomy Link Frequency
SiHa 1
HeLa 1
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 63 71.92 Quite High
Pain 7 58.60 Quite High
Inflammation 53 58.24 Quite High
COX-2 inhibitor 104 42.08 Quite Low
methotrexate 1 9.12 Low Low
vincristine 1 8.00 Low Low
cINOD 34 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 371 100.00 Very High Very High Very High
Cervical Cancer 4 95.92 Very High Very High Very High
INFLAMMATION 57 92.64 High High
Stress 11 90.08 High High
Skin Cancer 10 88.00 High High
Death 66 85.04 High High
Glioblastoma 47 66.88 Quite High
Pain 7 58.60 Quite High
Toxicity 7 54.44 Quite High
Cancer 263 53.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pro-apoptotic (e.g., Bax, Bcl-xS) and anti-apoptotic (e.g., Bcl-2, Bcl-xL) members of this family, respectively, promote and inhibit the translocation of cytochrome c from mitochondria to cytosol [15].
Localization (translocation) of Bcl-xL associated with apoptosis
1) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.41 Pain Relevance 0.24
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Localization (release) of Bcl-xL in HeLa associated with apoptosis
2) Confidence 0.09 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Localization (release) of Bcl-xL in SiHa associated with apoptosis
3) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox