INT18021

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 2.53
Pain Relevance 8.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 6
hippocampus 4
ACC 3
adrenal glands 2
nucleus 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 26 100.00 Very High Very High Very High
opioid receptor 25 100.00 Very High Very High Very High
mu opioid receptor 23 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
tolerance 11 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
midbrain 3 99.92 Very High Very High Very High
cocaine 5 99.80 Very High Very High Very High
Anterior cingulate cortex 3 99.80 Very High Very High Very High
narcan 8 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 4 99.98 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 1 99.98 Very High Very High Very High
Parkinsonian Disorders 1 98.48 Very High Very High Very High
Diabetes Mellitus 9 95.28 Very High Very High Very High
Parkinson's Disease 6 94.80 High High
Pain 3 92.36 High High
Weight Gain 3 86.44 High High
Urological Neuroanatomy 5 84.92 Quite High
Drug Dependence 3 77.88 Quite High
Targeted Disruption 1 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with naltrexone appears to produce a region-specific downregulation of MOR-1 mRNA levels, which may be secondary to the naltrexone-induced increase in mu receptor binding.
Positive_regulation (increase) of mu receptor Binding (binding) of
1) Confidence 0.70 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7583338 Disease Relevance 0.06 Pain Relevance 0.68
Diet-induced obesity increases mu opioid receptor binding in specific regions of the rat brain.
Positive_regulation (increases) of mu opioid receptor Binding (binding) of in brain associated with obesity and mu opioid receptor
2) Confidence 0.51 Published 2002 Journal Brain Res. Section Title Doc Link 12384255 Disease Relevance 0.54 Pain Relevance 0.30
A high correspondence between the mu-receptor mRNA and receptor binding distributions was observed in the nucleus of the accessory olfactory bulb, anterior olfactory nuclei, striatal patches of the nucleus accumbens and caudate-putamen, endopiriform nucleus, claustrum, diagonal band of Broca, globus pallidus, ventral pallidum, bed nucleus of stria terminalis, most thalamic nuclei, medial and posteriocortical medial amygdala, lateral, dorsomedial, posterior and mammillary nuclei of the hypothalamus, presubiculum, subiculum, rostral interpeduncular nucleus, median raphe, inferior colliculus, parabrachial nucleus, locus coeruleus, central grey, nucleus ambiguus, nucleus of the solitary tract, nucleus gracilis, nucleus cuneatus, and the dorsal motor nucleus of vagus.
Positive_regulation (correspondence) of mu-receptor Binding (binding) of in nucleus associated with nucleus accumbens, locus ceruleus, central grey, raphe, amygdala and parabrachial
3) Confidence 0.50 Published 1994 Journal Brain Res. Section Abstract Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.33
In contrast, mu receptor-stimulated [(35)S]GTPgammaS binding increased from 0.13 to 2.6 fmol/mg tissue over the same period, a 20-fold difference.
Positive_regulation (increased) of mu receptor Binding (binding) of
4) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15860573 Disease Relevance 0 Pain Relevance 0.26
In singly housed animals, mu receptor binding in Ket-injected rats increased in the frontal cortex and decreased in the hippocampus. (35)S-GTPgamma-S binding increased in the frontal cortex in both singly housed groups, but remained unchanged in the hippocampus.
Positive_regulation (increased) of mu receptor Binding (binding) of in frontal cortex
5) Confidence 0.50 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016710 Disease Relevance 0.05 Pain Relevance 0
This study investigated the relationship between mu receptor binding and mu agonist activation of G-proteins in the rat brain.
Spec (investigated) Positive_regulation (activation) of mu receptor Binding (binding) of in brain associated with agonist
6) Confidence 0.49 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10751548 Disease Relevance 0 Pain Relevance 0.36
Therefore, the third extracellular loop of MOR-1 appeared to be a key element for the binding of MOR-1 ligands.
Positive_regulation (element) of MOR-1 Spec (appeared) Binding (binding) of
7) Confidence 0.48 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14597234 Disease Relevance 0 Pain Relevance 0.38
Upon recovery from experimental parkinsonism, however, pallidal GABA(A) receptor binding returns to normal levels while mu-opioid receptor binding reflecting enkephalin release remains elevated.
Positive_regulation (elevated) of mu-opioid receptor Binding (binding) of associated with gaba, enkephalin, opioid receptor and parkinsonian disorders
8) Confidence 0.43 Published 2002 Journal Brain Res. Section Abstract Doc Link 12176171 Disease Relevance 0.57 Pain Relevance 0.62
Opioid mu-1 receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell.
Positive_regulation (increased) of Opioid mu-1 receptor Binding (binding) of in hippocampus associated with locus ceruleus, hippocampus and opioid
9) Confidence 0.41 Published 2001 Journal Neuroreport Section Abstract Doc Link 11733709 Disease Relevance 0.08 Pain Relevance 0.46
Despite this decrease in mu-activated G-proteins, [(3)H]naloxone binding demonstrated increased mu opioid receptor binding in several brain regions after heroin self-administration, and there was a significant decrease in mu receptor G-protein efficiency as expressed as a ratio between agonist-activated G-proteins and mu receptor binding.
Positive_regulation (increased) of mu opioid receptor Binding (binding) of in brain associated with agonist, mu opioid receptor and narcan
10) Confidence 0.37 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10844025 Disease Relevance 0.08 Pain Relevance 1.32
We previously demonstrated that chronic treatment of rats with the mu-opioid receptor agonist sufentanil induced pharmacological tolerance associated with mu-opioid receptor desensitization and down-regulation.
Positive_regulation (induced) of mu-opioid receptor Binding (associated) of associated with tolerance, agonist and opioid receptor
11) Confidence 0.34 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 0.67
Monocular enucleation also produces a significant lowering in mu receptor binding in other primary optic nuclei (the lateral geniculate nuclei, nucleus of the optic tract, and superficial layers of the superior colliculus) and in the pars principalis of the medial geniculate nucleus (description of changes in mu receptors in non-accessory optic primary optic nuclei will be considered elsewhere).
Positive_regulation (lowering) of mu receptor Binding (binding) of in medial geniculate nucleus
12) Confidence 0.31 Published 1990 Journal Vis. Neurosci. Section Abstract Doc Link 1963079 Disease Relevance 0 Pain Relevance 0.41
This rodent study defines opioid architecture in the perigenual and midcingulate divisions of ACC, relates mu-opioid receptor binding and G-protein activation, and localizes such binding to afferent axons with knife-cut lesions and specifically to noradrenergic terminals with immunotoxin lesions (anti-dopamine beta-hydroxylase-saporin; anti-DBH-saporin). [(3)H]Tyr-D-AlaGly-MePhe-Gly-ol (DAMGO) binding was highest in perigenual areas 32 and 24 with a peak in layer I.
Positive_regulation (activation) of mu-opioid receptor Binding (binding) of in ACC associated with dopamine, opioid receptor, anterior cingulate cortex and opioid
13) Confidence 0.27 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714867 Disease Relevance 0.09 Pain Relevance 0.56
In conclusion, our results provide novel mechanisms for the plasma glucose-lowering action of metformin, via an increase of beta-endorphin secretion from adrenal glands to stimulate opioid mu-receptor linkage, leading to an increase of GLUT-4 gene expression and an attenuation of hepatic PEPCK gene expression in STZ-induced diabetic rats.
Positive_regulation (increase) of opioid mu-receptor Binding (linkage) of in adrenal glands associated with diabetes mellitus and opioid
14) Confidence 0.24 Published 2006 Journal Diabetes Section Abstract Doc Link 16505249 Disease Relevance 0.79 Pain Relevance 0.32
Prenatal cocaine exposure increases mu-opioid receptor binding in dopaminergic terminal areas and enhances behavioral responsiveness to mu-opioid agonists.
Positive_regulation (increases) of mu-opioid receptor Binding (binding) of associated with newborn drug withdrawal syndrome, mu agonist, opioid receptor and cocaine
15) Confidence 0.14 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 11044590 Disease Relevance 0.10 Pain Relevance 0.56
Opioid mu-1 receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell.
Positive_regulation (increased) of Opioid mu-1 receptor in cingulate cortex Binding (binding) of in hippocampus associated with locus ceruleus, hippocampus and opioid
16) Confidence 0.14 Published 2001 Journal Neuroreport Section Abstract Doc Link 11733709 Disease Relevance 0.08 Pain Relevance 0.46
Opioid mu-1 receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell.
Positive_regulation (increased) of Opioid mu-1 receptor in locus coeruleus Binding (binding) of in hippocampus associated with locus ceruleus, hippocampus and opioid
17) Confidence 0.14 Published 2001 Journal Neuroreport Section Abstract Doc Link 11733709 Disease Relevance 0.08 Pain Relevance 0.46
Substitution on the biaryl moiety produced enhanced affinity for the mu-opioid receptor.
Positive_regulation (enhanced) of mu-opioid receptor Binding (affinity) of associated with opioid receptor
18) Confidence 0.05 Published 2005 Journal Medicinal chemistry (Sh?riqah (United Arab Emirates)) Section Abstract Doc Link 16787343 Disease Relevance 0 Pain Relevance 0.23

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