INT180233

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
palate 2
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 99.32 Very High Very High Very High
gABA 29 96.72 Very High Very High Very High
Glutamate 17 50.00 Quite Low
agonist 2 19.88 Low Low
GABAergic 2 13.72 Low Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 17 100.00 Very High Very High Very High
Targeted Disruption 4 99.68 Very High Very High Very High
Cleft Palate 4 98.08 Very High Very High Very High
Death 1 96.64 Very High Very High Very High
Cerebral Palsy 43 68.88 Quite High
Syndrome 14 50.00 Quite Low
Spasticity 20 43.76 Quite Low
Dyskinesias 1 33.68 Quite Low
Epilepsy 10 32.88 Quite Low
Neurological Disease 3 32.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is not inconsistent with the mouse Gad1 knockout where complete loss of Gad1 enzymatic function (~20% reduction of total Gad activity in the cerebral cortex) resulted in a cleft palate phenotype and neonatal death [28,30].
Negative_regulation (loss) of Negative_regulation (reduction) of Gad in palate associated with targeted disruption, cleft palate, generalized anxiety disorder, cerebral cortex and death
1) Confidence 0.14 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.60 Pain Relevance 0.14

General Comments

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