INT180238

Context Info Confidence 0.61 First Reported 2004 Last Reported 2009 Negated 0 Speculated 2 Reported most in Body Documents 13 Total Number 15 Disease Relevance 4.87 Pain Relevance 1.59

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1) transcription factor binding (Twist1)

Anatomy Link Frequency Th1 cells 6 lymphocytes 2 fibroblasts 2 Th2 cells 2 T cells 2 Twist1 (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 53 99.76 Inflammation 411 99.68 imagery 10 95.36 Neurotransmitter 15 91.80 Glutamate 19 88.68 gABA 29 87.08 cytokine 230 86.12 chemokine 40 84.72 Central nervous system 6 83.08 agonist 2 72.56

Disease Link Frequency Relevance Heat Epilepsy 10 100.00 Hypersensitivity 142 99.88 INFLAMMATION 421 99.68 Heart Rate Under Development 6 97.56 Periventricular Leukomalacia 5 94.80 Diabetes Mellitus 30 94.12 Diabetes Mellitus-type I 1 92.40 Paraplegia 5 92.16 Syndrome 15 90.32 Stiff-person Syndrome 2 90.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The requirement of NFAT for induction of twist1 expression in Th1 cells distinguishes control of twist1 expression in Th cells from its control in fibroblasts, where TNF-?

Regulation (control) of Gene_expression (expression) of twist1 in fibroblasts

1) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0

Th cell–specific twist1 expression in vivo

Regulation (specific) of Gene_expression (expression) of twist1

2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.06 Pain Relevance 0

Imprinting of the twist1 gene for reexpression in Th1 cells is reflected by increased acetylation of histone H3 and trimethylated histone H3 at lysine 4, in both resting and reactivated Th1 cells, as compared with Th2 cells (Fig.

Regulation (reflected) of Gene_expression (reexpression) of twist1 in Th2 cells

3) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0

Their imprinting for increased twist1 expression, maintained over time in individual patients, indicates a history of repeated restimulation and an endogenous regulation of proinflammatory effector functions under the control of NFAT and NF-?

Regulation (imprinting) of Gene_expression (expression) of twist1

4) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.09 Pain Relevance 0.05

Remarkably, expression of twist1 is highly up-regulated in CD3+CD4+ T cells isolated from inflamed tissues of patients with chronic inflammation of joints or gut.

Regulation (regulated) of Gene_expression (expression) of twist1 in T cells associated with inflammation

5) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.10 Pain Relevance 0.05

The key role of twist1 expression by Th1 cells for the self-limitation of Th1-induced inflammation is evident from the present analysis of murine models of inflammation.

Regulation (role) of Gene_expression (expression) of twist1 in Th1 cells associated with inflammation

6) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.51 Pain Relevance 0.39

For the initial expression of twist1 in Th1 cells, and its imprinting for reexpression in further restimulations, the concerted action of activated STAT4, NFAT1, and NF-?

Regulation (For) of Gene_expression (expression) of twist1 in Th1 cells

7) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0

Why is expression of twist1 up-regulated gradually?

Regulation (regulated) of Gene_expression (expression) of twist1

8) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.87 Pain Relevance 0.29

Furthermore, the cell viabilities decreased in a dose-dependent manner of Pa-PDT with IC50 value of 0.6 ?

Regulation (dependent) of Gene_expression (manner) of Pa-PDT

9) Confidence 0.32 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.88 Pain Relevance 0

In a murine transfer model of OVA-specific DTH, the effect of twist1 expression on the inflammation induced by transferred Th1 cells was analyzed.

Spec (analyzed) Regulation (effect) of Gene_expression (expression) of twist1 in Th1 cells associated with inflammation and hypersensitivity

10) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.50 Pain Relevance 0.19

Control of twist1 expression in Th1 lymphocytes

Regulation (Control) of Gene_expression (expression) of twist1 in lymphocytes

11) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0

The data illustrated in Fig. 2a show that there is no significant difference in survival of cells exposed to ETXp-PCI and PDT, suggesting that the observed cytotoxicity in both groups was due entirely to the PDT effect.

Regulation (due) of Gene_expression (effect) of PDT

12) Confidence 0.05 Published 2009 Journal J Neurooncol Section Body Doc Link PMC2773371 Disease Relevance 0.20 Pain Relevance 0

Finally, LTM is likely represented by LTP3 which should be influenced by cAMP-specific PDE inhibition

Regulation (specific) of Gene_expression (inhibition) of PDE

13) Confidence 0.04 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.33

PDE Pyridoxine-dependent epilepsy

Regulation (dependent) of Gene_expression (epilepsy) of PDE associated with epilepsy

14) Confidence 0.02 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.66 Pain Relevance 0.30

Chronic PDE inhibition, via the persistent activation of PDE5 promoters, may up-regulate PDE expression and, therefore, be associated with the development of drug tachyphylaxis (Moreland et al 1999).

Spec (may) Regulation (regulate) of Gene_expression (expression) of PDE

15) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0 Pain Relevance 0

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