INT180238

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 4.87
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 6
lymphocytes 2
fibroblasts 2
Th2 cells 2
T cells 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 53 99.76 Very High Very High Very High
Inflammation 411 99.68 Very High Very High Very High
imagery 10 95.36 Very High Very High Very High
Neurotransmitter 15 91.80 High High
Glutamate 19 88.68 High High
gABA 29 87.08 High High
cytokine 230 86.12 High High
chemokine 40 84.72 Quite High
Central nervous system 6 83.08 Quite High
agonist 2 72.56 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 10 100.00 Very High Very High Very High
Hypersensitivity 142 99.88 Very High Very High Very High
INFLAMMATION 421 99.68 Very High Very High Very High
Heart Rate Under Development 6 97.56 Very High Very High Very High
Periventricular Leukomalacia 5 94.80 High High
Diabetes Mellitus 30 94.12 High High
Diabetes Mellitus-type I 1 92.40 High High
Paraplegia 5 92.16 High High
Syndrome 15 90.32 High High
Stiff-person Syndrome 2 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The requirement of NFAT for induction of twist1 expression in Th1 cells distinguishes control of twist1 expression in Th cells from its control in fibroblasts, where TNF-?
Regulation (control) of Gene_expression (expression) of twist1 in fibroblasts
1) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Th cell–specific twist1 expression in vivo
Regulation (specific) of Gene_expression (expression) of twist1
2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.06 Pain Relevance 0
Imprinting of the twist1 gene for reexpression in Th1 cells is reflected by increased acetylation of histone H3 and trimethylated histone H3 at lysine 4, in both resting and reactivated Th1 cells, as compared with Th2 cells (Fig.
Regulation (reflected) of Gene_expression (reexpression) of twist1 in Th2 cells
3) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Their imprinting for increased twist1 expression, maintained over time in individual patients, indicates a history of repeated restimulation and an endogenous regulation of proinflammatory effector functions under the control of NFAT and NF-?
Regulation (imprinting) of Gene_expression (expression) of twist1
4) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.09 Pain Relevance 0.05
Remarkably, expression of twist1 is highly up-regulated in CD3+CD4+ T cells isolated from inflamed tissues of patients with chronic inflammation of joints or gut.
Regulation (regulated) of Gene_expression (expression) of twist1 in T cells associated with inflammation
5) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.10 Pain Relevance 0.05
The key role of twist1 expression by Th1 cells for the self-limitation of Th1-induced inflammation is evident from the present analysis of murine models of inflammation.
Regulation (role) of Gene_expression (expression) of twist1 in Th1 cells associated with inflammation
6) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.51 Pain Relevance 0.39
For the initial expression of twist1 in Th1 cells, and its imprinting for reexpression in further restimulations, the concerted action of activated STAT4, NFAT1, and NF-?
Regulation (For) of Gene_expression (expression) of twist1 in Th1 cells
7) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Why is expression of twist1 up-regulated gradually?
Regulation (regulated) of Gene_expression (expression) of twist1
8) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.87 Pain Relevance 0.29
Furthermore, the cell viabilities decreased in a dose-dependent manner of Pa-PDT with IC50 value of 0.6 ?
Regulation (dependent) of Gene_expression (manner) of Pa-PDT
9) Confidence 0.32 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.88 Pain Relevance 0
In a murine transfer model of OVA-specific DTH, the effect of twist1 expression on the inflammation induced by transferred Th1 cells was analyzed.
Spec (analyzed) Regulation (effect) of Gene_expression (expression) of twist1 in Th1 cells associated with inflammation and hypersensitivity
10) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.50 Pain Relevance 0.19
Control of twist1 expression in Th1 lymphocytes
Regulation (Control) of Gene_expression (expression) of twist1 in lymphocytes
11) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
The data illustrated in Fig. 2a show that there is no significant difference in survival of cells exposed to ETXp-PCI and PDT, suggesting that the observed cytotoxicity in both groups was due entirely to the PDT effect.
Regulation (due) of Gene_expression (effect) of PDT
12) Confidence 0.05 Published 2009 Journal J Neurooncol Section Body Doc Link PMC2773371 Disease Relevance 0.20 Pain Relevance 0
Finally, LTM is likely represented by LTP3 which should be influenced by cAMP-specific PDE inhibition
Regulation (specific) of Gene_expression (inhibition) of PDE
13) Confidence 0.04 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.33
PDE Pyridoxine-dependent epilepsy
Regulation (dependent) of Gene_expression (epilepsy) of PDE associated with epilepsy
14) Confidence 0.02 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.66 Pain Relevance 0.30
Chronic PDE inhibition, via the persistent activation of PDE5 promoters, may up-regulate PDE expression and, therefore, be associated with the development of drug tachyphylaxis (Moreland et al 1999).
Spec (may) Regulation (regulate) of Gene_expression (expression) of PDE
15) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0 Pain Relevance 0

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