INT180244

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gad2) Golgi apparatus (Gad2) plasma membrane (Gad2)
cytoplasm (Gad2)
Anatomy Link Frequency
pyramidal cells 1
neuron 1
Gad2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 86 100.00 Very High Very High Very High
Glutamate 35 100.00 Very High Very High Very High
Pyramidal cell 58 98.80 Very High Very High Very High
isoflurane 1 88.24 High High
interneuron 4 80.72 Quite High
agonist 8 62.56 Quite High
GABAergic 33 60.44 Quite High
Cholecystokinin 6 56.48 Quite High
Neurotransmitter 14 32.40 Quite Low
excitatory amino acid 2 29.32 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 99.66 Very High Very High Very High
Cerebral Palsy 86 86.56 High High
Spasticity 40 86.44 High High
Generalized Anxiety Disorder 35 84.88 Quite High
Dyskinesias 2 76.36 Quite High
Epilepsy 20 75.56 Quite High
Neurological Disease 7 74.80 Quite High
Muscle Rigidity 4 61.12 Quite High
Cognitive Disorder 4 58.64 Quite High
Ceroid Lipofuscinosis 6 53.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice expressing enhanced green fluorescent protein (eGFP) controlled by glutamate decarboxylase 65 (GAD65) promoter (Lopez-Benedito et al., 2004) or PV promoter (Meyer et al., 2002) were used.
Positive_regulation (enhanced) of GAD65 associated with targeted disruption and glutamate
1) Confidence 0.49 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2916217 Disease Relevance 0.10 Pain Relevance 0.23
The association of GAD67 with membranes requires formation of heteromeric links with GAD65, which are mediated via their N-terminal domains.
Positive_regulation (mediated) of GAD65
2) Confidence 0.41 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.77 Pain Relevance 0.16
In the CNS, GAD65 appears to be preferentially distributed in axon terminals and the associated synaptic vesicles, whereas GAD67 is also located in the cell bodies and more uniformly distributed throughout the neuron [24].
Positive_regulation (distributed) of GAD65 in neuron
3) Confidence 0.39 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.14 Pain Relevance 0.07
In these mice BDNF expression in the visual cortex is higher than in wt mice starting from very early postnatal ages and this correlates with a precocious development of IGI, as shown by the faster developmental increase in inhibitory postsynaptic currents and GABA biosynthetic enzyme GAD65 in the perisomatic region of pyramidal cells.
Positive_regulation (increase) of GAD65 in pyramidal cells associated with gaba and pyramidal cell
4) Confidence 0.22 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.06 Pain Relevance 0.16

General Comments

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