INT180249

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.69
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLUL) small molecule metabolic process (GLUL) lyase activity (GLUL)
Golgi apparatus (GLUL) intracellular (GLUL) ligase activity (GLUL)
Anatomy Link Frequency
neurons 1
astrocytes 1
GLUL (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 109 100.00 Very High Very High Very High
gABA 57 97.32 Very High Very High Very High
agonist 26 92.56 High High
Osteoarthritis 27 84.64 Quite High
cerebral cortex 2 84.64 Quite High
antagonist 6 77.12 Quite High
anesthesia 1 72.24 Quite High
GABA receptor 1 60.56 Quite High
cytokine 8 35.52 Quite Low
Neurotransmitter 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 3 88.88 High High
Disease 25 84.96 Quite High
Osteoarthritis 27 84.64 Quite High
Generalized Anxiety Disorder 17 84.52 Quite High
Cleft Palate 4 75.12 Quite High
Angelman Syndrome 1 58.16 Quite High
Targeted Disruption 8 57.84 Quite High
Cerebral Palsy 43 50.00 Quite Low
Syndrome 14 50.00 Quite Low
Epilepsy 12 44.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-stimulated cells, with an increase of 44-fold, and a subsequent 70% decrease in GS- and GS+ CS-treated cells.
Negative_regulation (decrease) of GS
1) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.22 Pain Relevance 0.07
Other mutations could be explored that may provide a more optimal reduction in Gs basal activity without affecting ligand-induced receptor activation.
Negative_regulation (reduction) of Gs
2) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.06 Pain Relevance 0.21
Unlike astrocytes, neurons cannot generate glutamine from glutamate owing to the lack of the glutamine synthetase enzyme [13].
Negative_regulation (lack) of glutamine synthetase enzyme in neurons associated with glutamate
3) Confidence 0.05 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0 Pain Relevance 0.29
Unlike astrocytes, neurons cannot generate glutamine from glutamate owing to the lack of the glutamine synthetase enzyme [13].
Negative_regulation (lack) of glutamine synthetase enzyme in astrocytes associated with glutamate
4) Confidence 0.02 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0 Pain Relevance 0.29
Gad1-/- mice demonstrated a decrease of ~20% in total glutamate decarboxylase activity at birth.
Negative_regulation (decrease) of glutamate associated with glutamate
5) Confidence 0.00 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.42 Pain Relevance 0.60

General Comments

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