INT18026

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.83
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprd1, Oprm1) plasma membrane (Oprd1) cytoplasm (Oprd1)
Anatomy Link Frequency
RVM 1
optic 1
Oprd1 (Rattus norvegicus)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
mu opioid receptor 9 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
agonist 6 99.96 Very High Very High Very High
Opioid 4 98.98 Very High Very High Very High
Rostroventromedial medulla 6 98.78 Very High Very High Very High
gABA 1 98.52 Very High Very High Very High
Inflammation 4 97.98 Very High Very High Very High
antagonist 5 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 3 98.12 Very High Very High Very High
INFLAMMATION 3 97.98 Very High Very High Very High
Hyperalgesia 2 92.28 High High
Urological Neuroanatomy 2 89.92 High High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, administration of the nonselective opioid receptor alkylating antagonist beta-chlornaltexamine (beta-CNA) over a similar range of doses was found to be nonselective for either delta radioligand, and produced greater inhibition of Oprm1 relative to Oprd1 binding, consistent with the nonselective pharmacological activity of this antagonist.
Oprd1 Binding (binding) of Oprm1 associated with antagonist and opioid receptor
1) Confidence 0.40 Published 2006 Journal Synapse Section Abstract Doc Link 16847946 Disease Relevance 0 Pain Relevance 0.60
These results suggest that persistent inflammatory injury increased the release in the RVM of opioid peptides with preferential affinity for the delta opioid receptor, which can interact in a synergistic or additive manner with an exogenously administered mu opioid receptor agonist.
opioid receptor Binding (interact) of mu opioid receptor in RVM associated with rostroventromedial medulla, inflammation, injury, agonist, mu opioid receptor, opioid receptor and opioid
2) Confidence 0.21 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11264327 Disease Relevance 0.65 Pain Relevance 1.96
All four of the accessory optic nuclei (AOS nuclei) are found to contain exceedingly high levels of mu opioid receptor binding with the selective radioligand [3H]-[D-Ala,MePhe4, Gly-ol5] (DAGO), low levels of kappa opioid receptor binding using the radioligand [3H]-[ethylketocyclazocine] (EKC) together with the competing agents [D-Pro4]-morphiceptin and [D-Ser2,Thr6]-Leu-enkephalin, and an absence of delta opioid receptor binding with the radioligand [3H]-[D-Ala2,D-Leu5]-enkephalin (DADLE) combined with the competing agent [D-Pro4]-morphiceptin.
delta opioid receptor Binding (binding) of mu opioid receptor in optic associated with kappa opioid receptor, mu opioid receptor, opioid receptor and enkephalin
3) Confidence 0.13 Published 1990 Journal Vis. Neurosci. Section Abstract Doc Link 1963079 Disease Relevance 0 Pain Relevance 0.61
On the other hand, the decrease of mu receptor binding and DOR-1 immunoreactivity observed after PTZ administration may be the result of enhanced levels of opioid peptides probably released over the kindling procedure.
DOR-1 Binding (binding) of mu receptor associated with opioid
4) Confidence 0.04 Published 1996 Journal Epilepsy Res. Section Abstract Doc Link 8985692 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

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