INT180264

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 12.81
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 1
node 1
melanocytes 1
head 1
body 1
BCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 3 97.76 Very High Very High Very High
palliative 3 85.12 High High
Bile 36 72.16 Quite High
spinal inflammation 1 22.80 Low Low
cryotherapy 8 6.36 Low Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 294 100.00 Very High Very High Very High
Basal Cell Carcinoma 164 100.00 Very High Very High Very High
Metastasis 70 99.80 Very High Very High Very High
Echinococcosis 84 99.66 Very High Very High Very High
Sunburn 31 98.68 Very High Very High Very High
Tinea 7 97.08 Very High Very High Very High
Pharyngitis 1 95.96 Very High Very High Very High
Cancer 150 95.64 Very High Very High Very High
Acne 2 95.44 Very High Very High Very High
Eczema 4 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It may also be possible that there is some behavioural correlate of body height related to sun exposure, such as participation in outdoor sporting activities [34], that increases the likelihood of developing BCC.
Positive_regulation (increases) of BCC in body associated with sunburn and skin cancer
1) Confidence 0.59 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1539017 Disease Relevance 1.07 Pain Relevance 0
Radiation induced BCC usually occurs with low to moderate doses of radiation for treatment of tinea capitis, hypertrophic tonsillitis, acne vulgaris, atopic dermatitis and hyperthyroidism.
Positive_regulation (induced) of BCC associated with pharyngitis, tinea, thyroid disease, acne, eczema and skin cancer
2) Confidence 0.57 Published 2008 Journal Indian Journal of Dermatology Section Body Doc Link PMC2763736 Disease Relevance 1.62 Pain Relevance 0
Several chemotherapeutic agents that have been used in metastatic BCC, including fluorouracil and combination of vincristine, bleomycine and prednisone [18].Kaufman suggested that cisplatin, alone or in combination is probably the most active in metastatic BCC [21].
Positive_regulation (active) of BCC associated with vincristine and basal cell carcinoma
3) Confidence 0.44 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 1.43 Pain Relevance 0.13
While the usual BCC that gives rise to metastases is a large, ulcerated, locally invasive BCC of the head and neck that recurs despite repeated surgical procedures or radiotherapy, these features are not absolute prerequisites for metastasis [14].
Neg (not) Positive_regulation (prerequisites) of BCC in head associated with metastasis and basal cell carcinoma
4) Confidence 0.44 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 2.00 Pain Relevance 0
Height seemed to be associated inconsistently with an increased risk of developing BCC, but the point estimates were not significant, and there were no significant tests for trend.
Positive_regulation (increased) of BCC associated with skin cancer
5) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1539017 Disease Relevance 1.18 Pain Relevance 0
Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in BCC.
Positive_regulation (occur) of BCC associated with skin cancer
6) Confidence 0.27 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3010650 Disease Relevance 0.87 Pain Relevance 0
While the usual BCC that gives rise to metastases is a large, ulcerated, locally invasive BCC of the head and neck that recurs despite repeated surgical procedures or radiotherapy, these features are not absolute prerequisites for metastasis [14].
Neg (not) Positive_regulation (prerequisites) of BCC in neck associated with metastasis and basal cell carcinoma
7) Confidence 0.15 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 2.00 Pain Relevance 0
However, the fact that we detected melan-A positive cells also in all melanin-negative BCCs suggests that BCC colonizing melanocytes are not activated in the means of melanin synthesis and transport in every case.
Neg (not) Positive_regulation (activated) of BCC in melanocytes associated with basal cell carcinoma
8) Confidence 0.09 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.82 Pain Relevance 0
One of the main surgical goals of LHC treatment is to manage BCC when they occur.
Positive_regulation (manage) of BCC associated with echinococcosis
9) Confidence 0.07 Published 2010 Journal BMC Surg Section Body Doc Link PMC2867769 Disease Relevance 0.68 Pain Relevance 0.07
When patients were older than 36.5 years-old (node 6) (the age cutoff chosen by the CART algorithm) only 20.6% could developp BCC, whereas almost 35.9% of those 36.5 years or younger (node 5) had BCC.
Positive_regulation (had) of BCC in node
10) Confidence 0.07 Published 2010 Journal BMC Surg Section Body Doc Link PMC2867769 Disease Relevance 1.13 Pain Relevance 0
BCC is a transcriptional activator of the three per (period) homologues, two cry (cryptochrome) homologues, and the rev-erb?
Positive_regulation (activator) of BCC
11) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0

General Comments

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