INT180264

Context Info Confidence 0.59 First Reported 2005 Last Reported 2011 Negated 3 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 12.81 Pain Relevance 0.20

Anatomy Link Frequency neck 1 node 1 melanocytes 1 head 1 body 1 BCC1 (Homo sapiens)

Pain Link Frequency Relevance Heat vincristine 3 97.76 palliative 3 85.12 Bile 36 72.16 spinal inflammation 1 22.80 cryotherapy 8 6.36 Pain 9 5.00 imagery 4 5.00 Inflammation 2 5.00 melanocortin 1 receptor 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Skin Cancer 294 100.00 Basal Cell Carcinoma 164 100.00 Metastasis 70 99.80 Echinococcosis 84 99.66 Sunburn 31 98.68 Tinea 7 97.08 Pharyngitis 1 95.96 Cancer 150 95.64 Acne 2 95.44 Eczema 4 94.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It may also be possible that there is some behavioural correlate of body height related to sun exposure, such as participation in outdoor sporting activities [34], that increases the likelihood of developing BCC.

Positive_regulation (increases) of BCC in body associated with sunburn and skin cancer

1) Confidence 0.59 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1539017 Disease Relevance 1.07 Pain Relevance 0

Radiation induced BCC usually occurs with low to moderate doses of radiation for treatment of tinea capitis, hypertrophic tonsillitis, acne vulgaris, atopic dermatitis and hyperthyroidism.

Positive_regulation (induced) of BCC associated with pharyngitis, tinea, thyroid disease, acne, eczema and skin cancer

2) Confidence 0.57 Published 2008 Journal Indian Journal of Dermatology Section Body Doc Link PMC2763736 Disease Relevance 1.62 Pain Relevance 0

Several chemotherapeutic agents that have been used in metastatic BCC, including fluorouracil and combination of vincristine, bleomycine and prednisone [18].Kaufman suggested that cisplatin, alone or in combination is probably the most active in metastatic BCC [21].

Positive_regulation (active) of BCC associated with vincristine and basal cell carcinoma

3) Confidence 0.44 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 1.43 Pain Relevance 0.13

While the usual BCC that gives rise to metastases is a large, ulcerated, locally invasive BCC of the head and neck that recurs despite repeated surgical procedures or radiotherapy, these features are not absolute prerequisites for metastasis [14].

Neg (not) Positive_regulation (prerequisites) of BCC in head associated with metastasis and basal cell carcinoma

4) Confidence 0.44 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 2.00 Pain Relevance 0

Height seemed to be associated inconsistently with an increased risk of developing BCC, but the point estimates were not significant, and there were no significant tests for trend.

Positive_regulation (increased) of BCC associated with skin cancer

5) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1539017 Disease Relevance 1.18 Pain Relevance 0

Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in BCC.

Positive_regulation (occur) of BCC associated with skin cancer

6) Confidence 0.27 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3010650 Disease Relevance 0.87 Pain Relevance 0

While the usual BCC that gives rise to metastases is a large, ulcerated, locally invasive BCC of the head and neck that recurs despite repeated surgical procedures or radiotherapy, these features are not absolute prerequisites for metastasis [14].

Neg (not) Positive_regulation (prerequisites) of BCC in neck associated with metastasis and basal cell carcinoma

7) Confidence 0.15 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC544837 Disease Relevance 2.00 Pain Relevance 0

However, the fact that we detected melan-A positive cells also in all melanin-negative BCCs suggests that BCC colonizing melanocytes are not activated in the means of melanin synthesis and transport in every case.

Neg (not) Positive_regulation (activated) of BCC in melanocytes associated with basal cell carcinoma

8) Confidence 0.09 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.82 Pain Relevance 0

One of the main surgical goals of LHC treatment is to manage BCC when they occur.

Positive_regulation (manage) of BCC associated with echinococcosis

9) Confidence 0.07 Published 2010 Journal BMC Surg Section Body Doc Link PMC2867769 Disease Relevance 0.68 Pain Relevance 0.07

When patients were older than 36.5 years-old (node 6) (the age cutoff chosen by the CART algorithm) only 20.6% could developp BCC, whereas almost 35.9% of those 36.5 years or younger (node 5) had BCC.

Positive_regulation (had) of BCC in node

10) Confidence 0.07 Published 2010 Journal BMC Surg Section Body Doc Link PMC2867769 Disease Relevance 1.13 Pain Relevance 0

BCC is a transcriptional activator of the three per (period) homologues, two cry (cryptochrome) homologues, and the rev-erb?

Positive_regulation (activator) of BCC

11) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0

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