INT18032

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 108
Total Number 118
Disease Relevance 30.78
Pain Relevance 89.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
spinal cord 7
ANP 3
brain 3
brainstem 3
hippocampus 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 1306 100.00 Very High Very High Very High
Opioid 748 100.00 Very High Very High Very High
opioid receptor 617 100.00 Very High Very High Very High
Dynorphin 460 100.00 Very High Very High Very High
agonist 312 100.00 Very High Very High Very High
antagonist 218 100.00 Very High Very High Very High
antinociception 197 100.00 Very High Very High Very High
Analgesic 157 100.00 Very High Very High Very High
Spinal cord 97 100.00 Very High Very High Very High
medulla 75 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 147 99.96 Very High Very High Very High
Stress 462 99.82 Very High Very High Very High
Ganglion Cysts 304 99.68 Very High Very High Very High
Respiratory Failure 23 99.66 Very High Very High Very High
Sleep Disorders 20 99.60 Very High Very High Very High
Anxiety Disorder 287 99.48 Very High Very High Very High
INFLAMMATION 317 99.40 Very High Very High Very High
Cognitive Disorder 40 99.24 Very High Very High Very High
Neuropathic Pain 165 99.20 Very High Very High Very High
Sprains And Strains 12 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of kappa opioid receptor mRNA upregulation in dorsal root ganglia with mechanical allodynia in mice following nerve injury.
Positive_regulation (upregulation) of kappa opioid receptor in dorsal root ganglia associated with pain, nervous system injury, allodynia and kappa opioid receptor
1) Confidence 0.70 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10984632 Disease Relevance 0.64 Pain Relevance 0.82
These results suggested that the central antinociceptive effects of paeoniflorin on formalin test in mice were mediated by the activation of kappa-opioid receptor and not related to the increase of intracellular calcium.
Positive_regulation (activation) of kappa-opioid receptor associated with kappa opioid receptor and antinociceptive
2) Confidence 0.70 Published 2001 Journal J Ethnopharmacol Section Abstract Doc Link 11297861 Disease Relevance 0.07 Pain Relevance 0.44
CONCLUSIONS: Neonatal stress increases KOR activation via the dynorphin system.
Positive_regulation (activation) of KOR
3) Confidence 0.70 Published 2009 Journal Neonatology Section Body Doc Link 19478529 Disease Relevance 0 Pain Relevance 0
RATIONALE: Exposure to inescapable stressors increases both the rewarding properties and self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but the effect of this signaling on other reinforcing agents remains unclear.
Positive_regulation (increases) of KOR associated with kappa opioid receptor and cocaine
4) Confidence 0.70 Published 2010 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 20401606 Disease Relevance 0.07 Pain Relevance 0.17
The above data indicate that activation of the kappa opioid receptor exerts an inhibitory effect on the pilocarpine-induced limbic seizures and neurotoxicity.
Positive_regulation (activation) of kappa opioid receptor associated with drug induced neurotoxicity, convulsion and kappa opioid receptor
5) Confidence 0.69 Published 1994 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 7894264 Disease Relevance 0.64 Pain Relevance 0.31
Thus, in the mouse, even partial and topographically restricted activation of CA3-KOR entails impairments in two different hippocampus-dependent tasks, indicating functional relevance of the kappa opioid system.
Positive_regulation (activation) of CA3-KOR in hippocampus associated with kappa opioid receptor, hippocampus and opioid
6) Confidence 0.69 Published 2007 Journal Neurobiol Learn Mem Section Abstract Doc Link 17374494 Disease Relevance 0.15 Pain Relevance 0.53
KOR activation in trigeminal root entry zone
Positive_regulation (activation) of KOR associated with kappa opioid receptor
7) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.27 Pain Relevance 0.78
KOR activation in the ipsilateral TREZ was blocked by the deletion of KOR or by NorBNI treatment (Fig. 5D, E, F).
Positive_regulation (activation) of KOR associated with kappa opioid receptor
8) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.34 Pain Relevance 1.00
These stimuli increase KOR-p-IR, and this response can be blocked by prior norBNI treatment or gene deletion of either GRK3, KOR or prodynorphin [3].
Positive_regulation (increase) of KOR-p-IR associated with kappa opioid receptor
9) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.26 Pain Relevance 0.91
To determine whether morphine activates kappa opioid receptors (KOR), a quantitative competitive RT-PCR procedure was utilized to quantify the KOR gene expression of morphine-treated cells.
Spec (whether) Positive_regulation (activates) of KOR associated with kappa opioid receptor and morphine
10) Confidence 0.67 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.18 Pain Relevance 1.45
Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by kappa-opioid receptor activation in mice.
Positive_regulation (activation) of kappa-opioid receptor associated with dopamine, kappa opioid receptor and morphine
11) Confidence 0.66 Published 1993 Journal Life Sci. Section Title Doc Link 8380621 Disease Relevance 0 Pain Relevance 0.86
These data demonstrate that salvinorin A is the active component of S. divinorum, selective for kappa(1)-opioid receptors, and that salvinorin A and specific structurally related analogs produce behavioral effects that require the kappa-opioid receptor.
Positive_regulation (require) of kappa-opioid receptor associated with kappa opioid receptor and opioid receptor
12) Confidence 0.65 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16672569 Disease Relevance 0.29 Pain Relevance 0.56
However, Bmax values of mu opioid receptor (MOR) and kappa opioid receptor (KOR) were increased in the brainstem, midbrain and spinal cord regions by repeated CWSS, without changing Kd values.
Positive_regulation (increased) of kappa opioid receptor in midbrain associated with stress, medulla, kappa opioid receptor, mu opioid receptor, midbrain and spinal cord
13) Confidence 0.65 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12788212 Disease Relevance 0.52 Pain Relevance 1.33
Stimulation of the KOR reduces voluntary ethanol drinking in rats (7).
Positive_regulation (Stimulation) of KOR associated with opioid receptor
14) Confidence 0.61 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.50 Pain Relevance 0.58
Mice exposed to stress and morphine showed region-specific increases in KOR-P immunoreactivity from 38 to 500% (p < 0.05 to p < 0.001), with marked gliosis.
Positive_regulation (increases) of KOR
15) Confidence 0.61 Published 2009 Journal Neonatology Section Body Doc Link 19478529 Disease Relevance 0.06 Pain Relevance 0
Overall, these results suggest that stress-induced activation of the KOR may be both necessary and sufficient to produce subsequent deficits in novel object recognition.
Positive_regulation (activation) of KOR associated with stress, cognitive disorder, eae and kappa opioid receptor
16) Confidence 0.59 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339623 Disease Relevance 1.08 Pain Relevance 0.75
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Positive_regulation (activation) of kappa-opioid receptor in tail associated with analgesic, kappa opioid receptor and morphine
17) Confidence 0.58 Published 1993 Journal Psychopharmacology (Berl.) Section Title Doc Link 7870894 Disease Relevance 0 Pain Relevance 0.73
Protein levels of KOR and DOR in the whole jejunum and mucosa were significantly increased after chronic inflammation.
Positive_regulation (increased) of KOR in jejunum associated with inflammation
18) Confidence 0.57 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16183704 Disease Relevance 0.71 Pain Relevance 1.09
Many reports have shown that stimulation of the kappa opioid receptor (KOR) suppresses development of analgesic tolerance to morphine.
Positive_regulation (stimulation) of kappa opioid receptor associated with analgesic, tolerance, kappa opioid receptor and morphine
19) Confidence 0.57 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.10 Pain Relevance 1.56
Many reports have shown that stimulation of the kappa opioid receptor (KOR) suppresses development of analgesic tolerance to morphine.
Positive_regulation (stimulation) of KOR associated with analgesic, tolerance, kappa opioid receptor and morphine
20) Confidence 0.57 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.10 Pain Relevance 1.57

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