INT180332

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 9.77
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Sla) cytoplasm (Sla)
Anatomy Link Frequency
liver 2
Sla (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 16 77.60 Quite High
Inflammation 24 64.96 Quite High
fibrosis 28 60.32 Quite High
abdominal pain 4 39.84 Quite Low
alcohol 9 35.12 Quite Low
tolerance 10 34.56 Quite Low
drug abuse 4 34.24 Quite Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 949 99.84 Very High Very High Very High
Hepatitis 122 99.34 Very High Very High Very High
Primary Sclerosing Cholangitis 35 98.76 Very High Very High Very High
Hepatitis C Virus Infection 227 97.64 Very High Very High Very High
Disease 185 95.52 Very High Very High Very High
Hypergammaglobulinemia 14 93.60 High High
Chronic Hepatitis 90 89.80 High High
Hypocalcemia 5 86.48 High High
Liver Disease 65 85.60 High High
Autoimmune Disease 66 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a recent study has shown that anti-SLA/LP autoantibodies can also be detected in AIH-2 and in children with PSC.
Gene_expression (detected) of SLA associated with autoimmune hepatitis and primary sclerosing cholangitis
1) Confidence 0.17 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.06 Pain Relevance 0
For this reason, subdivision into AIH-1 (ANA, SMA, p-ANCA and/or anti-SLA/LP positive) and AIH-2 (anti-LKM-1, anti-LKM-3 and/or anti-LC1 positive) is in common usage (Table 3).
Gene_expression (/) of SLA associated with autoimmune hepatitis
2) Confidence 0.14 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.76 Pain Relevance 0
These investigators used eukaryotically expressed tRNP ((Ser) Sec)/SLA as target in a radioligand assay (RLA) which is well known as a more sensitive test than ELISAs and immunoblot due to its ability to identify antibodies directed to conformational epitopes [81-83].
Gene_expression (expressed) of SLA
3) Confidence 0.13 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.15 Pain Relevance 0
However, a recent study from the United Kingdom [80] has shown that anti-SLA/LP autoantibodies can also be detected in AIH-2 and in children with PSC.
Gene_expression (detected) of SLA associated with autoimmune hepatitis and primary sclerosing cholangitis
4) Confidence 0.13 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.14 Pain Relevance 0
SLA is found in 100000 g supernatant of liver homogenate and represent a cytosolic protein which is neither organ nor species specific [72].
Gene_expression (found) of SLA in liver
5) Confidence 0.13 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.63 Pain Relevance 0.03
Drug-induced hepatitis superimposed on the presence of anti-SLA antibody: a case report

Introduction

Gene_expression (antibody) of anti-SLA associated with hepatitis
6) Confidence 0.04 Published 2008 Journal J Med Case Reports Section Title Doc Link PMC2246146 Disease Relevance 0.85 Pain Relevance 0.10
Occasionally anti-SLA antibodies have been found in pediatric AIH-2 and hepatitis C virus (HCV)-infected individuals.
Gene_expression (antibodies) of anti-SLA associated with autoimmune hepatitis, hepatitis c virus infection and hepatitis
7) Confidence 0.04 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2246146 Disease Relevance 1.45 Pain Relevance 0.03
Mons-BELGIUM) was confirmed by two different techniques; an ELISA with prokaryotically expressed SLA protein (Euroimmun UK.
Gene_expression (expressed) of SLA protein
8) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2246146 Disease Relevance 0.73 Pain Relevance 0
The presence of antineutrophil cytoplasmic autoantibodies (ANCA), antibodies against the asialoglycoprotein receptor (anti-ASGP-R) and anti-soluble liver antigens (anti-SLA) helps in the identification of ANA/SMA-negative patients.
Gene_expression (presence) of anti-SLA in liver
9) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2246146 Disease Relevance 0.98 Pain Relevance 0

General Comments

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