INT180343

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.49
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Codeine 16 84.84 Quite High
Morphine 44 83.92 Quite High
Analgesic 66 80.72 Quite High
antidepressant 4 74.28 Quite High
antiarrhythmic agent 2 73.60 Quite High
Oxycodone 70 69.08 Quite High
Opioid 64 66.20 Quite High
methadone 2 62.40 Quite High
Buprenorphine 2 61.80 Quite High
Paracetamol 6 50.88 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 169 98.28 Very High Very High Very High
Chronic Hepatitis 14 71.04 Quite High
Hepatitis C Virus Infection 43 67.68 Quite High
Infection 17 50.24 Quite High
Pain 111 50.00 Quite Low
Dizziness 6 45.76 Quite Low
Cirrhosis 3 29.64 Quite Low
Hepatitis 18 28.96 Quite Low
Autoimmune Disease 10 22.52 Low Low
Toxicity 2 18.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tapentadol did not undergo significant metabolism by CYP enzymes and did not inhibit or induce the activity of any of the CYP isoforms tested, with the exception of CYP2D6.41 Limited inhibition of CYP2D6 was observed with tapentadol, with competitive inhibition occurring with a Ki of 181 ?
Neg (exception) Negative_regulation (exception) of Negative_regulation (inhibition) of CYP2D6
1) Confidence 0.36 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004637 Disease Relevance 0 Pain Relevance 1.19
Tapentadol did not undergo significant metabolism by CYP enzymes and did not inhibit or induce the activity of any of the CYP isoforms tested, with the exception of CYP2D6.41 Limited inhibition of CYP2D6 was observed with tapentadol, with competitive inhibition occurring with a Ki of 181 ?
Neg (exception) Negative_regulation (exception) of Negative_regulation (inhibition) of CYP2D6
2) Confidence 0.36 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004637 Disease Relevance 0 Pain Relevance 1.19
However, due to failure of inhibition of CYP2D6 enzymatic activity using epitope specific antibodies and since the absorption of the above linear epitopes was unable to absorb inhibitory anti-CYP2D6 autoantibodies, the existence of additional conformational epitopes on CYP2D6 autoantigen has been postulated [95].
Negative_regulation (failure) of Negative_regulation (inhibition) of CYP2D6
3) Confidence 0.28 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.49 Pain Relevance 0

General Comments

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