INT180352

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.02
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (AMELX) signal transduction (AMELX) extracellular region (AMELX)
cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
Anatomy Link Frequency
liver 1
T cells 1
AMELX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 96.32 Very High Very High Very High
alcohol 5 75.92 Quite High
fibrosis 4 65.20 Quite High
Bile 2 27.44 Quite Low
tolerance 8 17.72 Low Low
cytokine 6 12.16 Low Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 305 100.00 Very High Very High Very High
INFLAMMATION 24 96.32 Very High Very High Very High
Necrosis 1 94.56 High High
Genetic Predisposition To Disease 4 88.84 High High
Alcoholic Liver Diseases 4 87.96 High High
Hepatitis Virus Infection 13 86.52 High High
Biliary Liver Cirrhosis 12 85.52 High High
Autoimmune Disease 48 80.68 Quite High
Disease 63 74.92 Quite High
Fibrosis 4 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding may suggest a possible immunopathogenetic involvement of anti-ASGP-R autoantibodies in AIH [69].
Spec (possible) Regulation (involvement) of AIH associated with autoimmune hepatitis
1) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.42 Pain Relevance 0.08
However, the HLA haplotypes considered as risk factors for type 1 AIH change in other regions of the world, leading to the supposition that different genetic associations are present in different populations and that the peptide specificity of the T cells in these populations also differs (for review see [27]).
Regulation (change) of AIH in T cells associated with autoimmune hepatitis
2) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.44 Pain Relevance 0
LKM-1 autoantibodies react with linear epitopes within cytochrome P450 2D6 (CYP2D6), a phase-I drug- and toxicant-metabolizing enzyme in the liver, and perhaps major antigen target of type 2 AIH.
Regulation (target) of AIH in liver associated with autoimmune hepatitis
3) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.16 Pain Relevance 0.14

General Comments

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