INT180353

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 15.34
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (AMELX) signal transduction (AMELX) extracellular region (AMELX)
cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
Anatomy Link Frequency
liver 2
stromal cells 1
AMELX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 99.98 Very High Very High Very High
alcohol 12 88.32 High High
fibrosis 4 77.60 Quite High
tolerance 23 75.36 Quite High
cytokine 7 69.80 Quite High
metalloproteinase 38 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 1488 100.00 Very High Very High Very High
INFLAMMATION 52 99.98 Very High Very High Very High
Cancer 75 99.68 Very High Very High Very High
Autoimmune Disease 118 98.60 Very High Very High Very High
Rheumatic Diseases 8 98.56 Very High Very High Very High
Hepatitis C Virus Infection 344 96.40 Very High Very High Very High
Disease 331 95.96 Very High Very High Very High
Hypopigmentation 16 95.52 Very High Very High Very High
Ovarian Cancer 100 94.72 High High
Hepatitis 160 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMG 386 is a peptibody that binds to and inhibits angiopoietin 1 and 2.
AMG Binding (binds) of
1) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.89 Pain Relevance 0
In clinical practice the recognition of AIH is of great importance since most of the patients respond favorably to antiinflammatory and immunosuppressive treatment.
AIH Binding (recognition) of associated with inflammation and autoimmune hepatitis
2) Confidence 0.04 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.18 Pain Relevance 0
These findings indicate that idiopathic AIH and AIH in APECED are characterized by different molecular targets of autoimmunity, which do not overlap.
AIH Binding (characterized) of associated with autoimmune disease and autoimmune hepatitis
3) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.74 Pain Relevance 0
Anti-CYP2A6 autoantibodies may be used as an indicator for APECED, if they are present in a patient with AIH.
AIH Binding (patient) of associated with autoimmune hepatitis
4) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.80 Pain Relevance 0
These findings indicate that idiopathic AIH and AIH in APECED are characterized by different molecular targets of autoimmunity, which do not overlap.
AIH Binding (idiopathic) of associated with autoimmune disease and autoimmune hepatitis
5) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.69 Pain Relevance 0
These findings indicate that idiopathic AIH and AIH in APECED are characterized by different molecular targets of autoimmunity, which do not overlap.
AIH Binding (idiopathic) of associated with autoimmune disease and autoimmune hepatitis
6) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.68 Pain Relevance 0
The latter further supports the low specificity of this autoantibody as a marker for AIH in APECED.
AIH Binding (marker) of associated with autoimmune hepatitis
7) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.75 Pain Relevance 0
In addition, recent novel findings dealing with the bone marrow hemopoietic progenitor cells and bone marrow stromal cells of patients with AIH suggests alternative therapeutic options even in refractory cases [139].
AIH Binding (dealing) of in stromal cells associated with autoimmune hepatitis
8) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.51 Pain Relevance 0
These findings indicate that idiopathic AIH and AIH in APECED are characterized by different molecular targets of autoimmunity, which do not overlap.
AIH Binding (characterized) of associated with autoimmune disease and autoimmune hepatitis
9) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.74 Pain Relevance 0
Taken together, the normal immune hyporesponsiveness in the liver can be attributed to a network of related mechanisms, one or more of which must be disrupted for the development of inflammation associated with AIH.
AIH Binding (associated) of in liver associated with autoimmune hepatitis and inflammation
10) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.15 Pain Relevance 0.24
Type 2 AIH is associated with antibodies against liver-kidney microsome 1 (LKM-1) and/or antibodies against liver cytosol 1 antigen (LC1) [4].
AIH Binding (associated) of in liver associated with autoimmune hepatitis
11) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.21 Pain Relevance 0.16

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