INT180361

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.03
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (AMELX) signal transduction (AMELX) extracellular region (AMELX)
cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
Anatomy Link Frequency
lymphocyte 1
AMELX (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 83 100.00 Very High Very High Very High
tolerance 13 94.92 High High
imagery 6 60.56 Quite High
Potency 10 59.52 Quite High
cytokine 13 44.56 Quite Low
Inflammation 68 44.20 Quite Low
alcohol 8 40.72 Quite Low
Analgesic 16 39.64 Quite Low
halothane 9 38.32 Quite Low
Rheumatism 1 36.48 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 542 100.00 Very High Very High Very High
Hepatitis 62 100.00 Very High Very High Very High
Hypopigmentation 4 99.80 Very High Very High Very High
Disease 130 99.32 Very High Very High Very High
Hepatitis C Virus Infection 86 97.24 Very High Very High Very High
Infection 43 97.08 Very High Very High Very High
Chronic Hepatitis 31 92.48 High High
Autoimmune Disease 77 91.92 High High
Toxicity 19 84.72 Quite High
INFLAMMATION 58 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No increase in incidence of treatment-emergent AEs was observed with increasing AMG 108 dose (Table 5).
Positive_regulation (increasing) of AMG
1) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991028 Disease Relevance 0.09 Pain Relevance 0
So far, anti-AADC autoantibodies have only been reported in APECED and their role in AIH and vitiligo as disease components of APECED deserve further investigation.

6.

Positive_regulation (role) of AIH associated with autoimmune hepatitis, hypopigmentation and disease
2) Confidence 0.04 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.12 Pain Relevance 0
For instance, CYP1A2 is the molecular target in dihydralazine-induced hepatitis and AIH as a component of APECED, CYP2D6 in AIH-2 and in some patients with HCV infection, CYP2A6 in APECED and in a proportion of patients with HCV infection and UGT1 in some cases of AIH-2 and chronic hepatitis D or C.
Positive_regulation (induced) of AIH associated with chronic hepatitis, autoimmune hepatitis, hepatitis c virus infection, infection and hepatitis
3) Confidence 0.04 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.94 Pain Relevance 0.05
For these reasons, evidence of toxicant-induced AIH is mostly based on the results of animal studies.
Positive_regulation (induced) of AIH associated with autoimmune hepatitis
4) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.70 Pain Relevance 0
Taken together these results showed that TCE exposure induced AIH, complete with lymphocyte infiltration and generation of antiliver antibodies, in MRL+/+ mice.

7.

Positive_regulation (induced) of AIH in lymphocyte associated with autoimmune hepatitis
5) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.02 Pain Relevance 0
This has led to the suggestion that some compounds that perturb these enzymes (e.g., certain drugs and xenobiotics) should be considered as potential environmental triggers of AIH.
Positive_regulation (triggers) of AIH associated with autoimmune hepatitis
6) Confidence 0.01 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.15 Pain Relevance 0
Since we are interested in identifying TRPA1 antagonists, we employed a 96-well format HTS assay to screen compound libraries and identified four TCEB compounds (AMG2504, AMG5445, AMG7160 and AMG9090) as potent antagonists of human TRPA1 activation by AITC.
Positive_regulation (activation) of AMG7160 associated with antagonist
7) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.24
Since we are interested in identifying TRPA1 antagonists, we employed a 96-well format HTS assay to screen compound libraries and identified four TCEB compounds (AMG2504, AMG5445, AMG7160 and AMG9090) as potent antagonists of human TRPA1 activation by AITC.
Positive_regulation (activation) of AMG2504 associated with antagonist
8) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.24
Since we are interested in identifying TRPA1 antagonists, we employed a 96-well format HTS assay to screen compound libraries and identified four TCEB compounds (AMG2504, AMG5445, AMG7160 and AMG9090) as potent antagonists of human TRPA1 activation by AITC.
Positive_regulation (activation) of AMG9090 associated with antagonist
9) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox