INT180362

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (AMELX) signal transduction (AMELX) extracellular region (AMELX)
cell adhesion (AMELX) proteinaceous extracellular matrix (AMELX)
AMELX (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 33 96.36 Very High Very High Very High
methotrexate 13 95.20 Very High Very High Very High
alcohol 1 42.48 Quite Low
Arthritis 10 25.00 Low Low
Pain 7 25.00 Low Low
tolerance 2 17.12 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 169 100.00 Very High Very High Very High
Rheumatoid Arthritis 33 96.36 Very High Very High Very High
Disease 54 92.20 High High
Autoimmune Disease 10 86.00 High High
Primary Sclerosing Cholangitis 7 80.08 Quite High
Liver Disease 9 68.16 Quite High
Injury 7 66.80 Quite High
Infection 26 43.04 Quite Low
Alcohol Addiction 1 42.72 Quite Low
Congenital Anomalies 4 39.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of the present study was to determine the effect of a long-acting IL-1 receptor inhibitor, AMG 108, in a double-blind, placebo-controlled, parallel-dosing study in patients with active RA who were receiving stable methotrexate (15 to 25 mg/week).


Negative_regulation (inhibitor) of AMG associated with rheumatoid arthritis and methotrexate
1) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991028 Disease Relevance 0.56 Pain Relevance 0.27
In general however, autoantibodies should not be used as a tool for monitoring of treatment or to predict AIH activity and outcome.
Negative_regulation (predict) of AIH associated with autoimmune hepatitis
2) Confidence 0.03 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.95 Pain Relevance 0

General Comments

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