INT180369

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.53
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ENAM) proteinaceous extracellular matrix (ENAM)
Anatomy Link Frequency
arm 1
ENAM (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 10 93.68 High High
metalloproteinase 2 70.68 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 845 100.00 Very High Very High Very High
Hepatitis 90 99.72 Very High Very High Very High
Hepatitis C Virus Infection 215 98.92 Very High Very High Very High
Disease 192 98.84 Very High Very High Very High
Infection 85 98.76 Very High Very High Very High
Autoimmune Disease 50 95.48 Very High Very High Very High
Dental Enamel Hypoplasia 2 94.68 High High
Chronic Hepatitis 70 94.16 High High
Targeted Disruption 1 84.88 Quite High
Disease Susceptibility 5 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another gene on the long arm of the X chromosome at the AIH3 locus must also be involved in enamel formation [16]. 4q11–q21 (AIH2, ENAM 4q21) is associated with both autosomal dominant and autosomal recessive inheritance patterns and within this 4q13.3 has been identified as being associated with an autosomal recessive inheritance [17-20].
AIH2 Binding (associated) of in arm
1) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1853073 Disease Relevance 0.46 Pain Relevance 0.04
Taking into consideration the genetic markers, it has been found that the association between HLA DR3 and AIH-2 is rather weaker than that reported in AIH-1, while an association between HLA DQ2 and AIH-2 has been reported [14,18,33,34].
AIH-2 Binding (association) of associated with autoimmune hepatitis
2) Confidence 0.06 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.85 Pain Relevance 0
Taking into consideration the genetic markers, it has been found that the association between HLA DR3 and AIH-2 is rather weaker than that reported in AIH-1, while an association between HLA DQ2 and AIH-2 has been reported [14,18,33,34].
AIH-2 Binding (association) of associated with autoimmune hepatitis
3) Confidence 0.06 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.86 Pain Relevance 0
For instance, CYP1A2 is the molecular target in dihydralazine-induced hepatitis and AIH as a component of APECED, CYP2D6 in AIH-2 and in some patients with HCV infection, CYP2A6 in APECED and in a proportion of patients with HCV infection and UGT1 in some cases of AIH-2 and chronic hepatitis D or C.
AIH-2 Binding (component) of associated with chronic hepatitis, autoimmune hepatitis, hepatitis c virus infection, infection and hepatitis
4) Confidence 0.06 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.96 Pain Relevance 0.05
In 1988 a second autoantibody marker of AIH-2 was recognized [19].
AIH-2 Binding (recognized) of associated with autoimmune hepatitis
5) Confidence 0.05 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 0.76 Pain Relevance 0
Interestingly, a patient with a high LKM-1 titer and autoantibodies directed against an epitope of amino acids 257–269, which are preferentially recognized by patients with AIH-2, showed exacerbation of the disease under interferon-alpha treatment.
AIH-2 Binding (recognized) of associated with autoimmune hepatitis and disease
6) Confidence 0.05 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.64 Pain Relevance 0

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