INT180379

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 31
Total Number 35
Disease Relevance 36.46
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Olr1) extracellular region (Olr1) cell adhesion (Olr1)
plasma membrane (Olr1)
Anatomy Link Frequency
blood 3
macrophages 2
colon 2
plasma 1
blood vessels 1
Olr1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 237 100.00 Very High Very High Very High
Inflammation 443 99.92 Very High Very High Very High
cytokine 175 99.40 Very High Very High Very High
psoriasis 189 98.48 Very High Very High Very High
cINOD 47 96.96 Very High Very High Very High
Inflammatory response 40 84.72 Quite High
Angina 34 74.96 Quite High
Demyelination 1 74.68 Quite High
rheumatoid arthritis 4 74.64 Quite High
COX2 13 69.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 523 99.92 Very High Very High Very High
Atherosclerosis 854 99.74 Very High Very High Very High
Adenoma 298 99.72 Very High Very High Very High
Colon Cancer 264 99.44 Very High Very High Very High
Carcinoma 221 99.34 Very High Very High Very High
Pathologic Constriction 40 99.34 Very High Very High Very High
Adhesions 135 99.28 Very High Very High Very High
Hypertension 31 99.16 Very High Very High Very High
Diabetes Mellitus 118 98.60 Very High Very High Very High
Psoriasis 318 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ox-LDL, for example, are scavenged through LOX-1 (Yoshida et al 1998), which is highly expressed in blood vessels in hypertension, diabetes, and dyslipidemia (Mehta and Li 2002).
Gene_expression (expressed) of LOX-1 in blood vessels associated with diabetes mellitus and hypertension
1) Confidence 0.36 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.10 Pain Relevance 0.12
Expression of VCAM-1 is induced by lysophosphatidylcholine present in Ox-LDL and by products of lipolysis (Kume et al 1992; Saxena et al 1992).
Gene_expression (present) of Ox-LDL
2) Confidence 0.32 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.12 Pain Relevance 0.15
In the present study we did not find any association between radical production and oxLDL in plasma.
Gene_expression (production) of oxLDL in plasma
3) Confidence 0.16 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.70 Pain Relevance 0
Accordingly, we explored whether there were any associations between the levels of MMP-9, MCP-1, ICAM-1, oxLDL, and free radicals in blood from the jugular vein, as well as variables related to atherosclerosis during endarterectomy.

2.

Gene_expression (levels) of oxLDL in blood associated with atherosclerosis and metalloproteinase
4) Confidence 0.14 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.95 Pain Relevance 0.21
The present study concerns the relationships between the production of free radicals during and after operation for stenosis of the carotid artery and blood levels of ICAM-1, MMP-9, MCP-1 and oxLDL.
Gene_expression (levels) of oxLDL in blood associated with pathologic constriction and metalloproteinase
5) Confidence 0.14 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.68 Pain Relevance 0.26
When analysing the relations between radical production and concentrations of MCP-1, ICAM-1, MMP-9 and oxLDL, mean values for all the OXANO concentrations measured during clamping and reperfusion and for the markers sampled before, during and after clamping were used.
Gene_expression (production) of oxLDL associated with metalloproteinase
6) Confidence 0.14 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.10 Pain Relevance 0.09
The production of ROS can be indirectly assessed by the levels of lipid peroxidation products such as lipid hydroperoxide (LHP), malondialdehyde (MDA), oxidized low-density lipoprotein (ox-LDL), and thiobarbituric acid (TBA) [87].
Gene_expression (oxidized) of ox-LDL
7) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.52 Pain Relevance 0.16
2-GP1-dependent anticardiolipin antibodies (aCL), as a consequence of structural similarity between ox-LDL surface structure and ?
Gene_expression (surface structure) of ox-LDL in surface structure
8) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.64 Pain Relevance 0.22
The accumulation of ox-LDL was detected in the upper epidermis of the involved skin from psoriatic patients by direct immune-fluorescent method [18].
Gene_expression (detected) of ox-LDL in skin associated with psoriasis
9) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.76 Pain Relevance 0.22
The present study concerns the relationships between the production of free radicals during and after operation for stenosis of the carotid artery and blood levels of ICAM-1, MMP-9, MCP-1 and oxLDL.
Gene_expression (levels) of oxLDL in carotid artery associated with pathologic constriction and metalloproteinase
10) Confidence 0.05 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.68 Pain Relevance 0.26
This series of events has been observed not only in macrophages treated with oxLDL, but in aggregated LDL (aggLDL) and CE dispersion particles (DISP) [45].
Gene_expression (with) of oxLDL in macrophages
11) Confidence 0.04 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.43 Pain Relevance 0
increased levels of oxLDL have been found in the serum of patients admitted with acute myocardial infarction, and immunohistochemical studies revealed the
Gene_expression (levels) of oxLDL associated with myocardial infarction
12) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.90 Pain Relevance 0.13
This is curious, because acLDL is endocytosed by MSR-A, as is oxLDL.
Gene_expression (curious) of oxLDL
13) Confidence 0.04 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.39 Pain Relevance 0
atherosclerosis induces the production of anti-oxLDL IgM antibodies, which
Gene_expression (production) of oxLDL associated with atherosclerosis
14) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.58 Pain Relevance 0
that IgM antibodies may bind to oxLDL preventing its binding and degradation by
Spec (may) Gene_expression (may) of oxLDL
15) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.68 Pain Relevance 0.03
oxidation-specific epitopes present on oxLDL are also presented on the surface
Gene_expression (present) of oxLDL
16) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.73 Pain Relevance 0.07
Auto-antibodies against oxLDL
Gene_expression (antibodies) of oxLDL
17) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.41 Pain Relevance 0.06
enhancement of oxLDL uptake, and an increase adhesion of these cells to
Gene_expression (uptake) of oxLDL associated with adhesions
18) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.24 Pain Relevance 0.09
OxLDL is known to be a very
Gene_expression (known) of OxLDL
19) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.31 Pain Relevance 0.08
and control of the production of oxLDL-induced antibodies by T cells.
Gene_expression (production) of oxLDL-induced in T cells
20) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.38 Pain Relevance 0

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