INT180382

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.94
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
dendritic cells 1
large granular lymphocyte 1
medulla oblongata 1
Fcgr3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 100 99.16 Very High Very High Very High
medulla 28 94.72 High High
cytokine 108 89.84 High High
Inflammation 84 78.52 Quite High
Thalamus 17 74.32 Quite High
Arthritis 34 68.96 Quite High
cerebral cortex 5 66.68 Quite High
Somatosensory cortex 12 62.40 Quite High
Inflammatory response 5 62.40 Quite High
Spinal cord 4 54.48 Quite High
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 644 100.00 Very High Very High Very High
Sprains And Strains 193 100.00 Very High Very High Very High
Targeted Disruption 80 100.00 Very High Very High Very High
Rheumatoid Arthritis 100 99.16 Very High Very High Very High
Acute Coronary Syndrome 2 99.00 Very High Very High Very High
Disease 289 98.00 Very High Very High Very High
Lymphocytosis 2 97.56 Very High Very High Very High
Diabetes Mellitus 13 97.44 Very High Very High Very High
Neurological Disease 4 94.00 High High
Infection 9 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RIII (CD16).10,11 In light of these crucial functions the TCR?
Gene_expression (.10) of CD16
1) Confidence 0.34 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.27 Pain Relevance 0.03
An intriguing observation is that dasatinib may modulate or suppress T-cell activation and proliferation.24 In a series of 18 patients treated with dasatinib, 8 patients developed chronic peripheral lymphocytosis, evidenced by natural killer (NK) cells or natural killer/T [NK/T]-cells with large granular lymphocyte morphologies and expression of CD16(+), CD56(+), CD3(?)
Gene_expression (expression) of CD16 in large granular lymphocyte associated with lymphocytosis
2) Confidence 0.21 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.66 Pain Relevance 0
In RA, notably, functional TLR-2 and TLR-4 are expressed on CD16+ synovial M?
Gene_expression (expressed) of CD16 associated with rheumatoid arthritis
3) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.80 Pain Relevance 0.35
/CD16+56+, CD3?
Gene_expression (/) of CD16
4) Confidence 0.09 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.06 Pain Relevance 0
Lectin-induced enhancement of IL-12 may indicate the selective activation of the Th1 pathway in dendritic cells derived from CD16?
Gene_expression (derived) of CD16 in dendritic cells
5) Confidence 0.09 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.06 Pain Relevance 0.04
The same BSE and BASE inocula used for Tgbov XV mice were injected intracerebrally and intraperitoneally into panels of four inbred mouse strains, including SJL, C57Bl/6, RIII, and VM mice.
Gene_expression (panels) of RIII associated with creutzfeldt jakob disease and sprains and strains
6) Confidence 0.05 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.57 Pain Relevance 0.13
and CD-16) was not reduced in BACE-/- cells.
Neg (not) Gene_expression (reduced) of CD-16
7) Confidence 0.05 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.13 Pain Relevance 0.03
Neuropathologic examination of BSE-infected SJL, C57Bl/6, RIII, and VM mice sacrificed at the terminal stage of disease revealed a spongiform encephalopathy with preferential involvement of the medulla oblongata, hypothalamus, and septum.
Spec (examination) Gene_expression (examination) of RIII in hypothalamus associated with medulla, creutzfeldt jakob disease and disease
8) Confidence 0.05 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.22 Pain Relevance 0.24
Four inbred mouse strains (SJL, RIII, C57Bl/6, and VM) and transgenic mice overexpressing bovine PrP with six octapeptide repeats on a murine PrP knockout background (Tgbov XV) [20] were used for the study.
Gene_expression (overexpressing) of RIII associated with targeted disruption and sprains and strains
9) Confidence 0.04 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.59 Pain Relevance 0.04
Neuropathologic examination of BSE-infected SJL, C57Bl/6, RIII, and VM mice sacrificed at the terminal stage of disease revealed a spongiform encephalopathy with preferential involvement of the medulla oblongata, hypothalamus, and septum.
Spec (examination) Gene_expression (examination) of RIII in medulla oblongata associated with medulla, creutzfeldt jakob disease and disease
10) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.22 Pain Relevance 0.24
(FcR) I, II, and III receptor expression levels in patients with acute coronary syndrome (ACS, n = 48), diabetes mellitus (DM, n = 59), or neither (C, n = 88).


Gene_expression (expression) of III receptor associated with acute coronary syndrome and diabetes mellitus
11) Confidence 0.01 Published 2004 Journal Immun Ageing Section Abstract Doc Link PMC544957 Disease Relevance 0.35 Pain Relevance 0

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