INT180388

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.21
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.43
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (ACCS)
Anatomy Link Frequency
coronary artery 2
synovial fluid 2
aorta 2
chest 2
ACCS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 89 99.62 Very High Very High Very High
Osteoarthritis 108 99.04 Very High Very High Very High
Inflammatory response 1 98.08 Very High Very High Very High
Angina 76 95.52 Very High Very High Very High
Inflammation 65 94.00 High High
ischemia 15 87.12 High High
Inflammatory stimuli 1 66.56 Quite High
imagery 15 50.00 Quite Low
Pain 10 37.52 Quite Low
depression 4 17.28 Low Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 295 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Osteoarthritis 114 99.04 Very High Very High Very High
Myocardial Infarction 160 98.80 Very High Very High Very High
INFLAMMATION 68 97.72 Very High Very High Very High
Death 26 97.72 Very High Very High Very High
Hypertension 19 96.08 Very High Very High Very High
Cv General 3 Under Development 43 95.52 Very High Very High Very High
Coronary Artery Disease 59 95.12 Very High Very High Very High
Heart Rate Under Development 25 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides ECG, the following 8 variables were found to be important for ACS prediction, and included in the model: age, chest discomfort at presentation, symptom duration and previous hypertension, angina pectoris, AMI, congestive heart failure or PCI/CABG.
Positive_regulation (important) of Gene_expression (prediction) of ACS in chest associated with heart rate under development, acute coronary syndrome, angina, hypertension and myocardial infarction
1) Confidence 0.21 Published 2006 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC1559601 Disease Relevance 0.96 Pain Relevance 0.18
From the clinical data collected for each patient, 18 variables available immediately at ED presentation (table 1) were chosen for further study based on their likely importance for ACS prediction.


Spec (likely) Positive_regulation (importance) of Gene_expression (prediction) of ACS associated with acute coronary syndrome
2) Confidence 0.21 Published 2006 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC1559601 Disease Relevance 0.74 Pain Relevance 0.25
Analysis of cytokines in synovial fluid after ACS injection
Positive_regulation (after) of Gene_expression (injection) of ACS in synovial fluid associated with cytokine
3) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.10 Pain Relevance 0.13
In line with earlier studies, IL-1ra levels of ACS in the current study were upregulated, although the reported relative increases in conditoned serum differed an order of a magnitude with those from the current study [12,17].
Positive_regulation (upregulated) of Gene_expression (levels) of ACS
4) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.34 Pain Relevance 0.16
Because a QTL for MCP-1 in the Framingham Heart Study overlaps with the GENECARD ACS linkage peak, we also tested the effect of rs10920501 on MCP-1 expression levels in the aorta, but found no evidence for any relationship (data not shown).


Positive_regulation (overlaps) of Gene_expression (overlaps) of GENECARD ACS in aorta associated with acute coronary syndrome
5) Confidence 0.13 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.27 Pain Relevance 0
In a prospective study, patients with ACS and elevated MPO levels had a statistically significant increase in the risk of death or MI during the first 72 hours, independently of troponin or CRP, suggesting that MPO provides independent prognostic information distinct from other established biomarkers.
Positive_regulation (elevated) of Gene_expression (levels) of ACS associated with acute coronary syndrome, urological neuroanatomy, myocardial infarction and death
6) Confidence 0.11 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.90 Pain Relevance 0.05
The suspicion of ACS had to be supported by ECG changes on admission, biochemical markers above the upper reference level or previously recognised coronary artery disease.13
Positive_regulation (suspicion) of Gene_expression (suspicion) of ACS in coronary artery associated with acute coronary syndrome and coronary artery disease
7) Confidence 0.06 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 1.33 Pain Relevance 0.22
Two pivotal studies have demonstrated the efficacy of fondaparinux as an anticoagulant in the setting of ACS, namely OASIS-5 in non-ST elevation ACS, and OASIS-6 in ST elevation myocardial infarction (MI).
Positive_regulation (elevation) of Gene_expression (setting) of ACS associated with acute coronary syndrome and myocardial infarction
8) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2856573 Disease Relevance 1.49 Pain Relevance 0.04
Two pivotal studies have demonstrated the efficacy of fondaparinux as an anticoagulant in the setting of ACS, namely OASIS-5 in non-ST elevation ACS, and OASIS-6 in ST elevation myocardial infarction (MI).
Positive_regulation (elevation) of Gene_expression (setting) of ACS associated with acute coronary syndrome and myocardial infarction
9) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2856573 Disease Relevance 1.49 Pain Relevance 0.04
Since all three receptors had uniform increases in expression levels in ACS compared with controls (with the FcR I ratio being the highest of the three), it may be reasonable to attribute a relatively minimal effect of acute inflammation to the ACS data.
Positive_regulation (increases) of Gene_expression (expression) of ACS associated with inflammation
10) Confidence 0.03 Published 2004 Journal Immun Ageing Section Body Doc Link PMC544957 Disease Relevance 0.81 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox