INT180415

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.92
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
keratinocytes 1
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 98.32 Very High Very High Very High
cytokine 17 97.80 Very High Very High Very High
agonist 18 53.44 Quite High
chemokine 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acantholysis 8 99.92 Very High Very High Very High
Apoptosis 54 99.60 Very High Very High Very High
Stress 14 99.46 Very High Very High Very High
INFLAMMATION 55 98.32 Very High Very High Very High
Bullous Skin Disease 39 98.20 Very High Very High Very High
Cancer 6 97.08 Very High Very High Very High
Injury 5 96.84 Very High Very High Very High
Necrosis 2 96.84 Very High Very High Very High
Blister 4 92.64 High High
Death 16 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mechanism(s) of up-regulation of RhoA in OA-challenged BSMs is not known here, inflammatory cytokines such as tumor necrosis factor-?
Regulation (regulation) of RhoA associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.53 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.38 Pain Relevance 0.12
The observed effect of simvastatin on protein isoprenylation of RhoA and Rac1 is due to a shortage of geranylgeranyl pyrophosphate, and it was previously shown that this shortage can be replenished by the addition of mevalonate or GGOH (Houten et al 2003b).
Regulation (effect) of RhoA
2) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.26 Pain Relevance 0
These findings suggest that the augmentation of Ca2+ sensitizing effect, probably via an up-regulation of RhoA protein, might be involved in the enhanced BSM contraction in antigen-induced airway hyperresponsiveness.



Regulation (regulation) of RhoA protein
3) Confidence 0.23 Published 2005 Journal Respir Res Section Abstract Doc Link PMC545934 Disease Relevance 0.14 Pain Relevance 0
In mammalian cells, 12/15LO products regulate small GTPases Ras and RhoA, MAP kinases, PKC, and transcription factor NF-?
Regulation (regulate) of RhoA
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.52 Pain Relevance 0.10
We have further evaluated whether Smad pathway could regulate RhoA-mediated apoptosis.
Regulation (regulate) of RhoA associated with apoptosis
5) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.84 Pain Relevance 0
ZOL impairs LPA-induced formation of stress fibers, a cellular effect dependent on RhoA geranyl-geranylation
Regulation (dependent) of RhoA associated with stress
6) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.32 Pain Relevance 0
Based on studies that used cultured keratinocytes, it appears that pemphigus autoantibodies trigger phosphorylation of p38 MAPK which in turn induces acantholysis by affecting downstream effectors such as RhoA or HSP27 [16, 18].
Regulation (affecting) of RhoA in keratinocytes associated with acantholysis and bullous skin disease
7) Confidence 0.11 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 1.46 Pain Relevance 0

General Comments

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