INT180419

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 88.96 High High
Arthritis 2 41.96 Quite Low
abdominal pain 2 41.52 Quite Low
headache 2 40.44 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 116 99.80 Very High Very High Very High
Fever 10 92.40 High High
INFLAMMATION 9 88.96 High High
Dementia 2 50.64 Quite High
Frailty 2 49.48 Quite Low
Ataxia 2 48.68 Quite Low
Diarrhoea 2 42.88 Quite Low
Vomiting 2 42.28 Quite Low
Arthritis 2 41.96 Quite Low
Abdominal Pain 2 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of RhoA protein in BSMs of OA-challenged mice
Regulation (challenged) of Positive_regulation (Upregulation) of RhoA protein
1) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
As observed with simvastatin, inhibition by GGTI also led to activation of total RhoA in both control and MKD cells (Fig. 2e).
Regulation (control) of Positive_regulation (activation) of RhoA associated with mevalonate kinase deficiency
2) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.32 Pain Relevance 0
Because small GTPases depend on isoprenylation for their proper signalling function, we studied the effect of MK deficiency on isoprenylation (i.e., geranylgeranylation) and activation of the two small GTPases, RhoA and Rac1.
Regulation (effect) of Positive_regulation (activation) of RhoA
3) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

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