INT180420

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
neuronal 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 95.08 Very High Very High Very High
Inflammatory response 1 91.04 High High
cINOD 50 80.96 Quite High
agonist 10 79.36 Quite High
COX-2 inhibitor 1 24.96 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 58 99.16 Very High Very High Very High
INFLAMMATION 26 95.08 Very High Very High Very High
Clostridium Infection 2 94.72 High High
Disease 38 88.32 High High
Cognitive Disorder 7 67.96 Quite High
Disorders Of Creatine Metabolism 1 67.60 Quite High
Asthma 8 5.00 Very Low Very Low Very Low
Fever 5 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Determination of RhoA protein level in BSM
Negative_regulation (Determination) of Gene_expression (level) of RhoA protein
1) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.16 Pain Relevance 0
Incubation with simvastatin decreased the levels of membrane-bound RhoA in both control and MKD cells (Fig. 1b).
Negative_regulation (decreased) of Gene_expression (levels) of RhoA associated with mevalonate kinase deficiency
2) Confidence 0.32 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.88 Pain Relevance 0
Recently it was shown that ibuprofen is able to suppress RhoA activity in neuronal cells through PPAR?
Negative_regulation (suppress) of Gene_expression (activity) of RhoA in neuronal
3) Confidence 0.19 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.60 Pain Relevance 0.55

General Comments

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