INT180422

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
neuronal 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 94.72 High High
Inflammatory response 1 90.68 High High
agonist 10 81.44 Quite High
cINOD 50 80.60 Quite High
COX-2 inhibitor 1 24.60 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 94.72 High High
Disease 38 90.40 High High
Cognitive Disorder 7 67.60 Quite High
Cancer 38 50.00 Quite Low
Clostridium Infection 2 49.00 Quite Low
Disorders Of Creatine Metabolism 1 21.88 Low Low
Sarcoma 14 5.80 Low Low
Metastasis 16 5.00 Very Low Very Low Very Low
Asthma 8 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the level of RhoA protein in BSMs, the samples (10 ?
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (level) of RhoA protein
1) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
By microarray analysis and western blotting we did not observe any evident change in ROCK or RhoA expression in tumorigenic cen3tel cells (data not shown); however, microarray and western blot analyses revealed that the cellular inhibitor of ROCK-I, Rnd3 (Riento et al. 2003), was expressed at lower levels in tumorigenic cen3tel cells compared to non-tumorigenic ones (Fig. 5A, B), suggesting that Rnd3 downregulation might play a role in the transition to the ROCK dependent mode of invasion.
Spec (evident) Regulation (change) of Gene_expression (expression) of RhoA
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
Recently it was shown that ibuprofen is able to suppress RhoA activity in neuronal cells through PPAR?
Regulation (through) of Gene_expression (activity) of RhoA in neuronal
3) Confidence 0.20 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.60 Pain Relevance 0.55

General Comments

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