INT180423

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 6.22
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
nerve 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 5 97.64 Very High Very High Very High
Dorsal horn 4 93.32 High High
substance P 26 91.88 High High
Neuropathic pain 8 90.20 High High
c fibre 16 82.16 Quite High
allodynia 2 67.68 Quite High
Thermal hyperalgesia 1 66.68 Quite High
Pain 8 50.00 Quite Low
orphanin 2 44.40 Quite Low
agonist 17 43.44 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 204 99.92 Very High Very High Very High
Nervous System Injury 17 99.82 Very High Very High Very High
Death 60 99.44 Very High Very High Very High
Mevalonate Kinase Deficiency 232 99.16 Very High Very High Very High
Demyelinating Disease 5 97.64 Very High Very High Very High
Clostridium Infection 6 90.64 High High
Neuropathic Pain 10 90.20 High High
Injury 10 86.84 High High
Nociception 13 75.44 Quite High
Asthma 8 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, protein expression of RhoA was significantly increased in the hyperresponsive BSMs.


Positive_regulation (increased) of Gene_expression (expression) of RhoA
1) Confidence 0.40 Published 2005 Journal Respir Res Section Abstract Doc Link PMC545934 Disease Relevance 0.16 Pain Relevance 0
These observations are in a good contrast with the previous findings that the nerve injury-induced activation of LPA1 receptor and RhoA causes functional changes in myelinated A-fibers, such as demyelination and up-regulation of Ca2+ channel ?
Positive_regulation (activation) of Gene_expression (receptor) of RhoA in nerve associated with demyelination and nervous system injury
2) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.17 Pain Relevance 0.98
The levels of RhoA protein in soluble fractions increased in both control and MKD cells (Fig. 1c).
Positive_regulation (increased) of Gene_expression (levels) of RhoA protein associated with mevalonate kinase deficiency
3) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.94 Pain Relevance 0
Activated RhoA and Rac1 assessment assays
Positive_regulation (Activated) of Gene_expression (assays) of RhoA
4) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0 Pain Relevance 0
Again, MKD cells were more sensitive to treatment with simvastatin, with markedly increased levels of active soluble RhoA and decreased levels of active membrane-bound RhoA already observed after incubation with low concentrations of simvastatin.
Positive_regulation (increased) of Gene_expression (levels) of RhoA associated with mevalonate kinase deficiency
5) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.64 Pain Relevance 0
Combination of membrane and soluble fraction separation and activated RhoA and Rac1 assessment assays
Positive_regulation (activated) of Gene_expression (assays) of RhoA
6) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0 Pain Relevance 0
RhoA/ROCK pathway mediates statin-dependent enhancement of Smad activation
Positive_regulation (enhancement) of Gene_expression (pathway) of RhoA
7) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.81 Pain Relevance 0
Cotransfection with DN-RhoA and Smad7 markedly suppressed DN-RhoA-induced cell death (Figure 4a and b).


Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of RhoA associated with death
8) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.84 Pain Relevance 0
Cotransfection with DN-RhoA and Smad7 markedly suppressed DN-RhoA-induced cell death (Figure 4a and b).


Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of RhoA associated with death
9) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.84 Pain Relevance 0
VSMCs were transfected with dominant negative (DN) expression vectors of the main geranylated proteins Rac-1, Cdc-42 and RhoA.
Positive_regulation (transfected) of Neg (negative) Gene_expression (expression) of RhoA
10) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.82 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox