INT180454

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.42
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2)
extracellular space (Apoa2) extracellular region (Apoa2)
Anatomy Link Frequency
plasma 1
Apoa2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 86.48 High High
Dismenorea 2 69.12 Quite High
Inflammation 12 59.88 Quite High
cytokine 2 29.72 Quite Low
agonist 3 19.12 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 47 100.00 Very High Very High Very High
Apoptosis 20 99.60 Very High Very High Very High
Renal Disease 2 99.04 Very High Very High Very High
Pressure And Volume Under Development 6 98.84 Very High Very High Very High
Cancer 34 98.76 Very High Very High Very High
Diabetes Mellitus 245 98.16 Very High Very High Very High
Hypercholesterolemia 1 98.16 Very High Very High Very High
Cataract 1 97.00 Very High Very High Very High
Nasopharynx Cancer 106 96.48 Very High Very High Very High
Hyperlipidemia 14 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In type 2 diabetic patients, triglyceride level increased significantly in C/T genotype in association with non significant decrease in HDL-C concentration.
Negative_regulation (decrease) of HDL associated with diabetes mellitus and disorder of lipid metabolism
1) Confidence 0.42 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 1.68 Pain Relevance 0
Non diabetic subjects having the heterozygous genotype (T/C) showed an increased triglyceride level and decreased HDL-C concentration.
Negative_regulation (decreased) of HDL associated with diabetes mellitus and disorder of lipid metabolism
2) Confidence 0.41 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 1.87 Pain Relevance 0
Elevated VLDL and LDL with depressed HDL (unpublished data) and renal dysfunction with microalbuminuria along with cataracts and other complications associated with progressive diabetes were also observed (data not shown).


Negative_regulation (depressed) of HDL associated with diabetes mellitus, renal disease, cataract and disorder of lipid metabolism
3) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 1.00 Pain Relevance 0
ApoG2 is a potent inhibitor of antiapoptotic Bcl-2 proteins and its treatment could remove the protective effect of Bcl-2 proteins and facilitate apoptosis.
Negative_regulation (inhibitor) of ApoG2 associated with apoptosis
4) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.23 Pain Relevance 0.06
Lipoprotein metabolism

Staggerer mice display lowered plasma HDL cholesterol levels associated with decreased plasma apoA-I and apoA-II concentration.

Negative_regulation (decreased) of apoA-II in plasma associated with disorder of lipid metabolism
5) Confidence 0.06 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.72 Pain Relevance 0.07
Based on our findings, we suggest that ApoG2-induced cell cycle arrest is dependent on ApoG2's downregulation of c-Myc expression.
Negative_regulation (downregulation) of ApoG2
6) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.92 Pain Relevance 0.07

General Comments

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