INT180459

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.11
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh23) plasma membrane (Cdh23) cilium (Cdh23)
Anatomy Link Frequency
cortex 3
Cdh23 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 93.84 High High
chemokine 3 92.76 High High
Inflammatory response 24 91.28 High High
Spinal cord 36 89.56 High High
Pain 3 69.28 Quite High
Inflammatory stimuli 3 64.76 Quite High
cytokine 6 59.16 Quite High
Hippocampus 27 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 99.88 Very High Very High Very High
Motor Neuron Diseases 321 99.16 Very High Very High Very High
Diabetes Mellitus 141 98.72 Very High Very High Very High
Congenital Anomalies 9 98.14 Very High Very High Very High
INFLAMMATION 60 93.84 High High
Increased Venous Pressure Under Development 3 90.88 High High
Coronary Artery Disease 93 88.04 High High
Hyperlipidemia 12 85.52 High High
Disorder Of Lipid Metabolism 42 84.36 Quite High
Hypoxia 18 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dynamic interfacial properties of apo A-V are consistent with the hypothesis that apo A-V impedes triglyceride particle assembly [7].
Gene_expression (properties) of A-V
1) Confidence 0.14 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
The absence of an unusual allele frequency of SNP3 in type 2 diabetic patients compared to non diabetic subjects, in spite of triglyceride level variation, shows that there is no association between apo A-V SNP3 polymorphism and the presence or absence of diabetes.
Gene_expression (polymorphism) of A-V associated with diabetes mellitus
2) Confidence 0.14 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.86 Pain Relevance 0
Studies on transgenic mice overexpressing human apo A-V showed a decreased level of triglyceride, whereas knock-out mice showed an increased level of triglyceride [3].
Gene_expression (overexpressing) of A-V associated with targeted disruption
3) Confidence 0.12 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
Expression profiling of the motor cortex of SALS patients
Gene_expression (Expression) of SALS in cortex
4) Confidence 0.08 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.63 Pain Relevance 0.04
The multifunctionality of EDN1 and EGR1 make the consequences of their differential expression in the SALS motor cortex ambiguous.
Gene_expression (expression) of SALS in cortex
5) Confidence 0.07 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.32 Pain Relevance 0.38
Here we address the importance of UMN abnormalities in SALS pathology and exploit the power of pathway-based significance tests by whole-genome expression profiling of the motor cortex of SALS patients.
Gene_expression (expression) of SALS in cortex associated with congenital anomalies
6) Confidence 0.07 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.66 Pain Relevance 0.10

General Comments

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