INT180465

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 9.49
Pain Relevance 0.16

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nucleoplasm (SNRNP70) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (cad) mRNA processing (SNRNP70)
RNA binding (SNRNP70) nucleus (SNRNP70) ligase activity (cad)
Anatomy Mention Frequency
plasma 2
SNRNP70 (Homo sapiens)
cad (Danio rerio)
Pain Term Frequency Confidence Heat
Inflammation 2 81.96 Quite High
cytokine 2 78.68 Quite High
Inflammatory marker 2 18.96 Low Low
drug abuse 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Angina 15 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Hyperlipidemia 11 100.00 Very High Very High Very High
Coronary Artery Disease 363 100.00 Very High Very High Very High
Diabetes Mellitus 323 99.48 Very High Very High Very High
Insulin Resistance 2 98.20 Very High Very High Very High
Disorder Of Lipid Metabolism 160 97.32 Very High Very High Very High
Hypertension 84 95.80 Very High Very High Very High
Disease 35 95.48 Very High Very High Very High
Adhesions 8 94.36 High High
Myocardial Infarction 43 90.00 High High
INFLAMMATION 4 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SNP rs2891168 was confirmed as associated with CAD (p < 0.0001) with a G-allele OR of 1.28 (95% CI 1.20-1.36), and SNP rs10811661 was associated with T2D (p = 0.04) with a T-allele OR of 1.19 (95%CI 1.01-1.41).
SNP Binding (associated) of CAD associated with coronary artery disease and diabetes mellitus
1) Confidence 0.03 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2871267 Disease Relevance 1.82 Pain Relevance 0
Despite the relation between CAD and hypertriglyceridemia the SNP 3 was not associated with CAD.


SNP 3 Binding (associated) of CAD associated with coronary artery disease and hyperlipidemia
2) Confidence 0.00 Published 2005 Journal Lipids Health Dis Section Abstract Doc Link PMC545942 Disease Relevance 1.31 Pain Relevance 0
Despite the relation between CAD and hypertriglyceridemia the SNP 3 was not associated with CAD.


SNP 3 Binding (associated) of CAD associated with coronary artery disease and hyperlipidemia
3) Confidence 0.00 Published 2005 Journal Lipids Health Dis Section Abstract Doc Link PMC545942 Disease Relevance 1.29 Pain Relevance 0
The APOC3-Sac1 SNP is an important genetic variant that is associated with CAD through its interaction with plasma lipids and other standard risk factors among Asian Indians.



SNP Binding (associated) of CAD in plasma associated with coronary artery disease
4) Confidence 0.00 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2556320 Disease Relevance 0.84 Pain Relevance 0
The APOC3-Sac1 SNP is an important genetic variant that is associated with CAD through its interaction with plasma lipids and other standard risk factors among Asian Indians.



SNP Binding (interaction) of CAD in plasma associated with coronary artery disease
5) Confidence 0.00 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2556320 Disease Relevance 0.84 Pain Relevance 0
In the present study, both the Sac1 SNP and -75G>A SNP, the minor alleles in particular, showed significant association with CAD by correspondence analysis; however the +83C>T SNP with a very low MAF (0.03) did not add any significant value to our data analysis and findings.
SNP Binding (association) of CAD associated with coronary artery disease
6) Confidence 0.00 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.28 Pain Relevance 0
In particular, the S128R polymorphism (SNP rs5361) of the E-selectin gene has been associated with CAD, premature CAD, as well as type 2 diabetes mellitus (DM2).
SNP rs5361 Binding (associated) of CAD associated with coronary artery disease and diabetes mellitus
7) Confidence 0.00 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.56 Pain Relevance 0.08
In particular, the S128R polymorphism (SNP rs5361) of the E-selectin gene has been associated with CAD, premature CAD, as well as type 2 diabetes mellitus (DM2).
SNP rs5361 Binding (associated) of CAD associated with coronary artery disease and diabetes mellitus
8) Confidence 0.00 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.56 Pain Relevance 0.08

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