INT180535

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.61
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BPI) extracellular region (BPI) cytoplasm (BPI)
Anatomy Link Frequency
nodes 2
neutrophils 1
BPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 24 99.10 Very High Very High Very High
fibrosis 1 93.12 High High
Inflammation 40 92.40 High High
dysesthesia 2 84.96 Quite High
Inflammatory mediators 2 73.88 Quite High
rheumatoid arthritis 2 69.56 Quite High
postherpetic neuralgia 15 60.04 Quite High
Inflammatory stimuli 1 59.48 Quite High
cytokine 21 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 22 99.10 Very High Very High Very High
Adhesions 2 98.20 Very High Very High Very High
Lymphopenia 2 97.20 Very High Very High Very High
Neuropathic Pain 3 95.08 Very High Very High Very High
Pulmonary Fibrosis 1 93.12 High High
INFLAMMATION 46 92.40 High High
Bacterial Respiratory Disease 2 88.36 High High
Herpes Zoster 80 88.12 High High
Dysesthesia 2 84.96 Quite High
Adult Respiratory Distress Syndrome 2 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The BPI conducted by PINT relies on putatively identical nodes (PIN) sets (see section ‘The pathways integration rule’), but not on any gene or protein expression data.
Gene_expression (conducted) of BPI in nodes
1) Confidence 0.52 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
The BPI conducted by PINT relies on putatively identical nodes (PIN) sets (see section ‘The pathways integration rule’), but not on any gene or protein expression data.
Neg (not) Gene_expression (relies) of BPI in nodes
2) Confidence 0.52 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
The mean pain intensity that the patients experienced, as assessed by the BPI, was scored as a 3.2 (SD: 2.3).
Gene_expression (assessed) of BPI associated with pain
3) Confidence 0.45 Published 2010 Journal BMC Fam Pract Section Body Doc Link PMC2874789 Disease Relevance 1.80 Pain Relevance 0.63
Interestingly, in Gram-negative bacteria sPLA2-IIA cannot directly attack the phospholipids of the intact cell membranes, but needs the cooperative action of neutrophils which produce bactericidal permeability-increasing protein (BPI) to support this function (Wright et al 1990; Laine et al 1999).
Gene_expression (produce) of bactericidal permeability-increasing protein in neutrophils
4) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.84 Pain Relevance 0.15
There is also up-regulation of expression of genes, such us, Bactericidal Permeability Increasing Protein (BPI) and Carcino Embryonic Antigen related Cell adhesion Molecule 8 (CEACAM 8 or CD66b).
Gene_expression (expression) of BPI associated with adhesions
5) Confidence 0.17 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.97 Pain Relevance 0.13

General Comments

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