INT180566

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DMD) cytosol (DMD) extracellular space (COMP)
extracellular region (COMP) proteinaceous extracellular matrix (COMP) cell adhesion (COMP)
Anatomy Link Frequency
cartilage 1
COMP (Homo sapiens)
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 35 90.08 High High
Inflammation 4 54.28 Quite High
Osteoarthritis 1 16.12 Low Low
metalloproteinase 2 7.44 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 9 97.32 Very High Very High Very High
Rheumatoid Arthritis 35 90.08 High High
Necrosis 1 88.24 High High
Cancer 1 87.88 High High
Disease 12 79.44 Quite High
INFLAMMATION 4 54.28 Quite High
Osteoarthritis 1 16.12 Low Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As was discussed in a previous report [5], an explanation of the positive association between COMP and BMD at entry into the study could be due to a strong relation between osteoporosis and severe joint damage with decreased presence of articular cartilage and consequently reduced cartilage turnover.
COMP Binding (association) of BMD in cartilage associated with osteoporosis
1) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.72 Pain Relevance 0.15

General Comments

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