INT180578

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.15
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEYL) protein binding transcription factor activity (HEYL) DNA binding (HEYL)
transcription factor binding (HEYL) cytoplasm (HEYL)
Anatomy Link Frequency
rim 1
body 1
HEYL (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 35 89.84 High High
Rheumatism 1 87.96 High High
Pain 5 80.24 Quite High
cva 7 75.08 Quite High
anesthesia 1 55.92 Quite High
withdrawal 1 31.84 Quite Low
transdermal 8 16.36 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporotic Fractures 17 99.40 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 6 96.72 Very High Very High Very High
Breast Cancer 46 96.40 Very High Very High Very High
Carcinoma In Situ 1 93.16 High High
Lobular Carcinoma 1 92.84 High High
Hyperplasia 10 92.00 High High
Rheumatoid Arthritis 35 89.84 High High
Rheumatic Diseases 1 87.96 High High
Endometriosis (extended) 28 84.92 Quite High
Disease 12 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the strong body of evidence supporting the effectiveness of HRT in preventing osteoporotic fractures, the challenge facing physicians is whether the benefits of HRT outweigh its risks.


Regulation (effectiveness) of HRT in body associated with osteoporotic fractures
1) Confidence 0.06 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.99 Pain Relevance 0.06
In a randomized, controlled study of raloxifene and HRT, transiliac bone biopsies were obtained following double tetracycline labelling at baseline and 1 year.
Regulation (controlled) of HRT
2) Confidence 0.06 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.53 Pain Relevance 0.10
However, we had previously placed the contour line as close as possible to the dark-to-light color change in the HRT reflectance image in order to define the margin of the ONH [12], but for the present study we ensured that the contour line was placed on stable rim tissue on top of the ring of Elschnig [27], which is often most discernable from the underside of the 3D image, as a ridge circumscribing the ONH.
Spec (possible) Regulation (change) of HRT in rim
3) Confidence 0.03 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2045691 Disease Relevance 0.13 Pain Relevance 0
The patients were not receiving and had not used in the preceding 2 years drugs affecting bone metabolism (HRT or bisphosphonates), except calcium and vitamin D3, which were allowed.
Regulation (affecting) of HRT
4) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.65 Pain Relevance 0.27
All women had a normal mammogram at the time of aspiration and had undergone no change in hormone replacement therapy (HRT) or ingested any selective estrogen receptor modulator or aromatase inhibitor for a period of 6 months before RPFNA.
Neg (no) Regulation (change) of HRT
5) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.85 Pain Relevance 0.06

General Comments

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