INT180580

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.49
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEYL) protein binding transcription factor activity (HEYL) DNA binding (HEYL)
transcription factor binding (HEYL) cytoplasm (HEYL)
Anatomy Link Frequency
joint 1
HEYL (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 7 99.04 Very High Very High Very High
Pain 4 98.84 Very High Very High Very High
headache 2 98.60 Very High Very High Very High
rheumatoid arthritis 35 98.32 Very High Very High Very High
transdermal 3 91.04 High High
Acupuncture 55 86.72 High High
cINOD 9 84.32 Quite High
cytokine 1 80.16 Quite High
Inflammation 4 77.68 Quite High
endometriosis 2 76.88 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 99.80 Very High Very High Very High
Breast Cancer 95 99.76 Very High Very High Very High
Endometrial Cancer 11 99.42 Very High Very High Very High
Pain 3 98.84 Very High Very High Very High
Headache 4 98.60 Very High Very High Very High
Rheumatoid Arthritis 35 98.32 Very High Very High Very High
Disease 33 96.64 Very High Very High Very High
Hypercalcemia 13 94.44 High High
Cardiovascular Disease 23 94.20 High High
Endometriosis (extended) 73 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, HRT is associated with a host of negative side effects.
HRT Binding (associated) of
1) Confidence 0.17 Published 2008 Journal Trials Section Abstract Doc Link PMC2631496 Disease Relevance 0.17 Pain Relevance 0.15
Women who had started taking HRT before their menstrual periods had stopped were considered eligible when they had been taking HRT for 12 months.
HRT Binding (taking) of
2) Confidence 0.05 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1828722 Disease Relevance 0.52 Pain Relevance 0.08
A meta-analysis of 30 randomised controlled trials conducted between 1966 and 2002 assessed mortality associated with HRT by age above or below 60 at trial entry.
HRT Binding (associated) of
3) Confidence 0.05 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1828722 Disease Relevance 0.46 Pain Relevance 0
We also evaluated HRT as a confounder because of its contribution to cumulative hormonal exposure and its association with breast cancer risk [19].
HRT Binding (association) of associated with breast cancer
4) Confidence 0.03 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2656898 Disease Relevance 0.68 Pain Relevance 0.46
We have recently reported that treatment with HRT for 2 years in postmenopausal women with RA significantly improved BMD and also indicated a protective effect on joint destruction [10].
HRT Binding (treatment) of in joint associated with rheumatoid arthritis
5) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 1.02 Pain Relevance 0.25
Combined estrogen plus progestin HRT, and not estrogen alone, is associated with increases mammographic density in postmenopausal women [15,16].
HRT Binding (associated) of
6) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.36 Pain Relevance 0
Moreover, estrogen replacement, especially if administered long-term, may lead to an increased risk of breast and, when unopposed by progestins, endometrial cancers.33 Other side effects often associated with HRT are fluid retention, breast pain, headache, and resumption of menstrual cycle.
HRT Binding (associated) of associated with pain, pressure and volume under development, headache and endometrial cancer
7) Confidence 0.00 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 1.29 Pain Relevance 0.20

General Comments

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