INT180592

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEYL) protein binding transcription factor activity (HEYL) DNA binding (HEYL)
transcription factor binding (HEYL) cytoplasm (HEYL)
Anatomy Link Frequency
cartilage 2
HEYL (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 76.64 Quite High
rheumatoid arthritis 70 76.04 Quite High
Osteoarthritis 2 75.76 Quite High
metalloproteinase 4 67.08 Quite High
corticosteroid 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 76.64 Quite High
Rheumatoid Arthritis 70 76.04 Quite High
Osteoarthritis 2 75.76 Quite High
Disease 24 71.52 Quite High
Cancer 2 8.96 Low Low
Necrosis 2 8.40 Low Low
Osteoporosis 18 5.00 Very Low Very Low Very Low
Hypercalcemia 12 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present investigation, CTX-II in the urine decreased significantly within the HRT group, a finding that implies that HRT has a protective effect on cartilage.
Negative_regulation (decreased) of Gene_expression (group) of HRT in cartilage
1) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.30 Pain Relevance 0.15
The HRT group presented a marked decrease in serum levels of COMP, both between the HRT and control group (P = 0.003) and within the HRT group (P = 0.003).
Negative_regulation (decrease) of Gene_expression (group) of HRT
2) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0

General Comments

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