INT180678

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.69
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
knee joints 2
microglia 2
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 33 99.62 Very High Very High Very High
metalloproteinase 91 96.92 Very High Very High Very High
Arthritis 45 95.28 Very High Very High Very High
Osteoarthritis 114 95.04 Very High Very High Very High
Inflammation 40 89.24 High High
chemokine 8 83.48 Quite High
cytokine 20 83.00 Quite High
cerebral cortex 8 73.76 Quite High
ischemia 53 64.92 Quite High
Dismenorea 2 64.32 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 30 99.62 Very High Very High Very High
Injury 66 96.40 Very High Very High Very High
Arthritis 45 95.28 Very High Very High Very High
Osteoarthritis 117 95.04 Very High Very High Very High
Hyperplasia 9 92.28 High High
INFLAMMATION 46 89.24 High High
Disease Progression 3 87.76 High High
Fibrosis 24 86.28 High High
Cerebral Infarction 5 64.92 Quite High
Dysmenorrhea 2 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can stimulate PAI-1, inhibiting the protease degradation of the ECM.
Negative_regulation (inhibiting) of Protein_catabolism (degradation) of ECM
1) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.06 Pain Relevance 0.12
Anti-FGF8 antibody blocked this FGF8 with IL-1-induced degradation of the ECM.
Negative_regulation (blocked) of Protein_catabolism (degradation) of ECM
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.95 Pain Relevance 0.46
Another possible mechanism of the MMP inhibitor could be that a loss of ECM proteolysis derived from microglia limited their ability to migrate through the ECM to the region of injury (or other unknown mechanisms).
Negative_regulation (loss) of Protein_catabolism (proteolysis) of ECM in microglia associated with injury
3) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.66 Pain Relevance 0.37
The degradation of the ECM by 100 ng/ml FGF8 was inhibited dose-dependently by anti-FGF8 antibody at 1 to 10 ?
Negative_regulation (inhibited) of Protein_catabolism (degradation) of ECM
4) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.06 Pain Relevance 0
Injection of FGF8 into rat knee joints induced the degradation of the ECM, which was suppressed by anti-FGF8 antibody.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of ECM in knee joints
5) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.62 Pain Relevance 0.35
Hepatic fibrosis arises when TIMPs inhibit ECM degradation excessively (13).
Negative_regulation (inhibit) of Protein_catabolism (degradation) of ECM associated with fibrosis and cirrhosis
6) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.33 Pain Relevance 0.31

General Comments

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