INT180683

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.25
Pain Relevance 1.03

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enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
synovial fluid 2
chondrocytes 2
knee joints 2
ECM 2
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 266 98.72 Very High Very High Very High
Arthritis 105 93.52 High High
Inflammation 50 93.48 High High
metalloproteinase 62 86.88 High High
Sciatic nerve 9 68.92 Quite High
Dismenorea 2 65.00 Quite High
cytokine 21 56.80 Quite High
chemokine 4 56.24 Quite High
Pain 36 42.88 Quite Low
fibrosis 7 28.28 Quite Low
Disease Link Frequency Relevance Heat
Injury 41 99.92 Very High Very High Very High
Osteoarthritis 273 98.72 Very High Very High Very High
Cancer 8 95.44 Very High Very High Very High
Metastasis 2 93.84 High High
Arthritis 105 93.52 High High
INFLAMMATION 58 93.48 High High
Hyperplasia 21 92.76 High High
Disease Progression 7 92.00 High High
Dysmenorrhea 2 65.00 Quite High
Pain 36 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can stimulate PAI-1, inhibiting the protease degradation of the ECM.
Positive_regulation (stimulate) of Protein_catabolism (degradation) of ECM
1) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.12
The cell proliferation and differentiation process is also an event involving uPA catalytic ECM degradation that increases cell migration by activating MMP 9 [21].
Positive_regulation (increases) of Protein_catabolism (degradation) of ECM in ECM
2) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.27 Pain Relevance 0.03
FGF8 dose-dependently induced ECM degradation.
Positive_regulation (induced) of Protein_catabolism (degradation) of ECM
3) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.07 Pain Relevance 0
A concentration of FGF8 (100 ng/ml) that caused ECM degradation was used.
Positive_regulation (caused) of Protein_catabolism (degradation) of ECM
4) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
In cultured chondrocytes, degradation of the ECM induced by FGF8 was further enhanced by a small amount of IL-1.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of ECM in chondrocytes
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.85 Pain Relevance 0.38
Degradation of the ECM was promoted in the presence of FGF8.
Positive_regulation (promoted) of Protein_catabolism (Degradation) of ECM
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.25 Pain Relevance 0.08
These data indicate that the injection of FGF8 causes degradation of the ECM of the articular cartilage and release of S-GAG into the synovial fluid.
Positive_regulation (causes) of Protein_catabolism (degradation) of ECM in synovial fluid
7) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.12 Pain Relevance 0.06
FGF8 at 10 ng/ml did not induce ECM degradation.
Neg (not) Positive_regulation (induce) of Protein_catabolism (degradation) of ECM
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0 Pain Relevance 0
Injection of FGF8 into rat knee joints induced the degradation of the ECM, which was suppressed by anti-FGF8 antibody.
Positive_regulation (induced) of Protein_catabolism (degradation) of ECM in knee joints
9) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.62 Pain Relevance 0.35

General Comments

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