INT180693

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp3) extracellular region (Timp3) cytoplasm (Timp3)
Timp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 99.64 Very High Very High Very High
cva 2 13.60 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 2 76.32 Quite High
Stroke 57 75.84 Quite High
Middle Cerebral Artery Infarction 31 61.88 Quite High
Death 5 48.28 Quite Low
Hemorrhage 1 13.60 Low Low
Pressure And Volume Under Development 2 11.84 Low Low
Injury 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of TIMP3 associated with metalloproteinase
1) Confidence 0.22 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.08 Pain Relevance 0.05
Top regulated genes include TIMP3 (+2.39 fold), ITGB2 (+1.21 fold), COL17A1 (+1.27 fold), GZMB (+1.74 fold), JAG1 (-2.09 fold), CSF-1 (-1.70 fold), SLP1 (-1.70 fold), FCGR2B (-1.51 fold), and PIK3CD (-1.31 fold).



Regulation (regulated) of TIMP3
2) Confidence 0.19 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.32 Pain Relevance 0

General Comments

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