INT1807

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Context Info
Confidence 0.38
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.04
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Bcar1) plasma membrane (Bcar1) cytoplasm (Bcar1)
Anatomy Link Frequency
neuronal 1
brain 1
Bcar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 18 98.64 Very High Very High Very High
antagonist 5 98.02 Very High Very High Very High
Serotonin 18 97.76 Very High Very High Very High
Inflammation 10 97.44 Very High Very High Very High
noradrenaline 2 97.36 Very High Very High Very High
Pain 2 96.60 Very High Very High Very High
Dopamine 2 96.44 Very High Very High Very High
IPN 2 94.28 High High
Morphine 10 92.40 High High
fluoxetine 2 90.52 High High
Disease Link Frequency Relevance Heat
Aggression 30 99.76 Very High Very High Very High
INFLAMMATION 12 97.44 Very High Very High Very High
Pain 2 96.60 Very High Very High Very High
Inflammatory Pain 2 94.28 High High
Hyperalgesia 10 88.76 High High
Opiate Addiction 2 86.24 High High
Neuropathic Pain 6 81.08 Quite High
Nociception 2 80.72 Quite High
Morphine Dependence 4 76.92 Quite High
Recurrence 2 34.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore hypothesized that inhibition of CAs with acetazolamide (ACTZ) increases the tissue pH and reverses inflammation-induced pain.
Negative_regulation (inhibition) of CAs associated with pain and inflammation
1) Confidence 0.38 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15743922 Disease Relevance 0.64 Pain Relevance 0.46
It is possible that the inhibition of ion channels and/or the inhibition of spinally located CAs contribute to the observed antihyperalgesia.
Negative_regulation (inhibition) of CAs
2) Confidence 0.38 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15743922 Disease Relevance 0.96 Pain Relevance 0.76
Our experimental data are compatible with the assumption that long lasting depletion of brain CAs is compensated for by induction of neuronal supersensitivity for noradrenaline (NA) and dopamine (DA).
Negative_regulation (depletion) of CAs in neuronal associated with dopamine and noradrenaline
3) Confidence 0.29 Published 1975 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 238137 Disease Relevance 0.22 Pain Relevance 0.97
With either method, "acute" depletion of brain CAs resulted in reduced intensity of withdrawal.
Negative_regulation (depletion) of CAs in brain associated with withdrawal
4) Confidence 0.29 Published 1975 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 238137 Disease Relevance 0.15 Pain Relevance 0.94
Crk-associated substrate (CAS) was down-regulated by PGF2?
Negative_regulation (down-regulated) of Crk-associated substrate
5) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
also significantly inhibited Crk-associated kinase (CAS), calcium calmodulin kinase II (CAMKII) and IV (CAMKIV), phospholipase C1, and protein phosphatases such as phosphatase 2A and protein tyrosine phosphatase 1B (Table 3).


Negative_regulation (inhibited) of CAS
6) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.14
Additionally, a subset of PCs display a unique firing pattern known as the “trimodal” state (Womack and Khodakhah, 2004; Loewenstein et al., 2005; McKay et al., 2007), where an initial tonic SS section is immediately followed by a volley of CaS, and subsequently followed by a quiescent period (Figure 1C), or a bimodal state without the initial tonic SS period and consisting entirely of bursts of CaS followed by periods of quiescence (Figure 1D).
Negative_regulation (volley) of CaS
7) Confidence 0.20 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876879 Disease Relevance 0 Pain Relevance 0.06
On the contrary, the other re-uptake inhibitor used, citalopram, appeared to have a dual effect and decreased LF and CAS, while increasing TPP.
Negative_regulation (decreased) of CAS
8) Confidence 0.19 Published 1991 Journal Indian J. Exp. Biol. Section Abstract Doc Link 1839019 Disease Relevance 1.05 Pain Relevance 0.65
However, the other serotonin receptor antagonist used, metergoline, which blocks both 5-HT1 and 5-HT2 receptor subtypes, attenuated FIA per se but decreased only CAS in apomorphine induced increase in FIA.
Negative_regulation (decreased) of CAS associated with antagonist, aggression and serotonin
9) Confidence 0.14 Published 1991 Journal Indian J. Exp. Biol. Section Abstract Doc Link 1839019 Disease Relevance 1.02 Pain Relevance 0.62

General Comments

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