INT180712

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.52
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) response to stress (Sgk1) cytoplasm (Sgk1)
Anatomy Link Frequency
joint 2
male germ cell 1
Sgk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 66 99.04 Very High Very High Very High
Inflammation 34 97.90 Very High Very High Very High
IPN 10 96.60 Very High Very High Very High
Serotonin 12 92.04 High High
Arthritis 2 79.44 Quite High
Pain 32 74.60 Quite High
chemokine 4 64.08 Quite High
cytokine 7 62.88 Quite High
metalloproteinase 6 60.92 Quite High
adenocard 3 58.48 Quite High
Disease Link Frequency Relevance Heat
Repression 4 100.00 Very High Very High Very High
Arthritis 6 97.90 Very High Very High Very High
Inflammatory Pain 10 96.60 Very High Very High Very High
Targeted Disruption 2 90.08 High High
INFLAMMATION 31 81.76 Quite High
Hypersensitivity 6 77.96 Quite High
Pain 32 74.60 Quite High
Nociception 4 23.40 Low Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that, after induction of peripheral joint inflammation, MeCP2 was phosphorylated in rat superficial dorsal horn and lamina I/III projection neurones, and that expression of SGK1, a protein under transcriptional repression by MeCP2, also expressed in lamina I/III projection neurones, increased in the superficial dorsal horn in an inflammatory pain state [7].
Gene_expression (expression) of SGK1 in joint associated with inflammation, ipn, repression, dorsal horn and arthritis
1) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.75 Pain Relevance 0.64
We have previously reported that, after induction of peripheral joint inflammation, MeCP2 was phosphorylated in rat superficial dorsal horn and lamina I/III projection neurones, and that expression of SGK1, a protein under transcriptional repression by MeCP2, also expressed in lamina I/III projection neurones, increased in the superficial dorsal horn in an inflammatory pain state [7].
Gene_expression (expressed) of SGK1 in joint associated with inflammation, ipn, repression, dorsal horn and arthritis
2) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.77 Pain Relevance 0.65
down regulated the expression of serum glucocorticoid kinase (SGK), casein kinase I, extracellular signal-regulated kinase (ERK-1), male germ cell-associated kinase (MAK), and Wee tyrosine kinase.
Gene_expression (expression) of SGK in male germ cell
3) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.12

General Comments

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