INT180718

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 7.76
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SARS) ligase activity (SARS) cytoplasm (SARS)
cytosol (SARS) peptidase activity (ACE2) extracellular space (ACE2)
Anatomy Link Frequency
respiratory tract epithelium 1
lung 1
respiratory 1
SARS (Homo sapiens)
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 95.40 Very High Very High Very High
headache 13 62.60 Quite High
corticosteroid 15 41.76 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 436 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 67 99.16 Very High Very High Very High
Infection 136 98.20 Very High Very High Very High
Pressure And Volume Under Development 11 96.68 Very High Very High Very High
Respiratory Failure 30 95.56 Very High Very High Very High
Coronavirus Infection 101 95.44 Very High Very High Very High
INFLAMMATION 21 95.40 Very High Very High Very High
Influenza Virus Infection 66 92.44 High High
Respiratory Syncytial Virus 57 91.88 High High
Lower Respiratory Tract Infection 26 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it was shown that a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), efficiently binds the S1 domain of the SARS-CoV S protein.
SARS-CoV S protein Binding (binds) of angiotensin-converting enzyme 2 associated with severe acute respiratory syndrome
1) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.09 Pain Relevance 0
Recently, it was shown that a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), efficiently binds the S1 domain of the SARS-CoV S protein.
SARS-CoV S protein Binding (binds) of ACE2 associated with severe acute respiratory syndrome
2) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.07 Pain Relevance 0
SARS-CoV binds to CD209L (L-SIGN) and ACE-2, two functional receptors on the respiratory tract epithelium [46,47].
SARS Binding (binds) of ACE-2 in respiratory tract epithelium associated with severe acute respiratory syndrome
3) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 1.89 Pain Relevance 0.11
The binding of SARS-CoV to ACE-2, along with lower levels of MBL, leads to higher viral levels, increased alveolar edema, and the severe acute respiratory failure associated with SARS-CoV.
SARS Binding (binding) of ACE-2 in respiratory associated with pressure and volume under development, severe acute respiratory syndrome and respiratory failure
4) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 1.69 Pain Relevance 0.04
ACE-2 has a key protective role in acute lung injury by reducing alveolar fluid, and thus the binding of SARS-CoV to ACE-2 may contribute to the dysregulation of fluid balance in the alveolar space [48].
SARS Binding (binding) of ACE-2 in lung associated with severe acute respiratory syndrome and adult respiratory distress syndrome
5) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.02 Pain Relevance 0.10

General Comments

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