INT18073

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 1.98
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
plasma 1
neurons 1
sensory nerve 1
skin 1
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
c fibre 14 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
TRP channel 9 100.00 Very High Very High Very High
bradykinin 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 98.76 Very High Very High Very High
Pain 41 98.24 Very High Very High Very High
Neurotransmitter 5 96.84 Very High Very High Very High
Serotonin 5 95.16 Very High Very High Very High
Cannabinoid 11 91.76 High High
Clonidine 1 91.64 High High
Disease Link Frequency Relevance Heat
Nociception 7 100.00 Very High Very High Very High
Malignant Neoplastic Disease 1 99.84 Very High Very High Very High
Cancer 5 91.04 High High
Pain 40 90.52 High High
Depression 9 89.76 High High
Fatigue 19 78.88 Quite High
Rickets 2 75.00 Quite High
Temporomandibular Joint Syndrome 2 75.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 60.72 Quite High
Eczema 1 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rise in calcitriol concentration preceded the elevation of Pi in serum, not, however, the increase of TRP.
Positive_regulation (increase) of TRP
1) Confidence 0.67 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1963876 Disease Relevance 0.38 Pain Relevance 0.12
Stretching without prior deactivation may increase TrP sensitivity.
Spec (may) Positive_regulation (increase) of TrP
2) Confidence 0.67 Published 2003 Journal Acupunct Med Section Abstract Doc Link 14620302 Disease Relevance 0.43 Pain Relevance 0.30
Pretreatment with hydrocortisone (100 mg, orally 11 h before) also blunts the GH response to L-TRP.
Positive_regulation (response) of TRP
3) Confidence 0.49 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041314 Disease Relevance 0.09 Pain Relevance 0.23
These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1.
Spec (may) Positive_regulation (activate) of TRP in skin associated with nociception, c fibre, qutenza and bradykinin
4) Confidence 0.49 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15488288 Disease Relevance 0.16 Pain Relevance 0.74
Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat.
Positive_regulation (activated) of TRP
5) Confidence 0.45 Published 2002 Journal Cell Section Abstract Doc Link 11893340 Disease Relevance 0.09 Pain Relevance 0.16
However, activation of TRP/TRPV1 channels can also lead to desensitization and loss of sensory nerve activity.
Positive_regulation (activation) of TRP in sensory nerve
6) Confidence 0.45 Published 2009 Journal Curr Vasc Pharmacol Section Abstract Doc Link 19149636 Disease Relevance 0 Pain Relevance 0.72
Patapoutian, ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures, Cell 112 (2003) 819-829; S.
Positive_regulation (activated) of TRP in neurons associated with nociception
7) Confidence 0.45 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17499848 Disease Relevance 0.34 Pain Relevance 0.44
Stronger cooling also activates another TRP channel, TRP (ankyrin-like)-1, (TRPA1), which has been suggested to underlie cold nociception.
Positive_regulation (activates) of TRP associated with nociception and trp channel
8) Confidence 0.38 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 16075243 Disease Relevance 0.10 Pain Relevance 0.05
Previous studies have demonstrated that elevation in plasma [FFA] displaces Trp from binding to albumin and consequently increases the free-Trp:LNAA ratio into the plasma [17,18,30,31].
Positive_regulation (increases) of Trp in plasma
9) Confidence 0.27 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.08 Pain Relevance 0.15
Stronger cooling also activates another TRP channel, TRP (ankyrin-like)-1, (TRPA1), which has been suggested to underlie cold nociception.
Positive_regulation (activates) of TRP associated with nociception and trp channel
10) Confidence 0.25 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 16075243 Disease Relevance 0.10 Pain Relevance 0.05
TRPM8 was initially identified as a prostate-specific TRP channel that was upregulated in malignant tissue [14].
Positive_regulation (upregulated) of TRP associated with malignant neoplastic disease and trp channel
11) Confidence 0.10 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.10 Pain Relevance 0.24
The conservation of Trp may also be due to the formation of stacking and consequent stabilization.
Positive_regulation (conservation) of Trp
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.06 Pain Relevance 0
However, Km(Trp) values for TPH2A and TPH2B were close to the previously reported constants and consistently higher than for TPH1 (Table S3) [20], [39].
Positive_regulation (values) of Trp
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.05 Pain Relevance 0.14

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