INT180734

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 6.83
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Emid1) Golgi apparatus (Emid1) endoplasmic reticulum (Emid1)
proteinaceous extracellular matrix (Emid1) biological_process (Emid1)
Anatomy Link Frequency
spike 1
epithelial cells 1
Emid1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 84.52 Quite High
Inflammation 12 84.12 Quite High
chemokine 3 82.28 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 637 100.00 Very High Very High Very High
Disease 189 99.96 Very High Very High Very High
Pulmonary Disease 30 99.28 Very High Very High Very High
Infection 190 96.40 Very High Very High Very High
Immunization 9 88.48 High High
Apoptosis 4 84.96 Quite High
INFLAMMATION 12 84.12 Quite High
Bone Fracture 3 81.20 Quite High
Congenital Anomalies 11 76.40 Quite High
Coronavirus Infection 104 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, the fact that recombinant icSARS-CoV produced disease clinically similar to its Urbani parent supports the hypothesis that the molecular clone recapitulates the disease phenotype in the macaque.
Gene_expression (produced) of CoV associated with disease
1) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1435788 Disease Relevance 1.18 Pain Relevance 0
We cannot exclude the possibility that icSARS-CoV produces more significant pulmonary disease, but the difference in findings is more likely related to route of infection and dose.
Gene_expression (produces) of CoV associated with pulmonary disease and infection
2) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1435788 Disease Relevance 1.04 Pain Relevance 0
Wild-type SARS-CoV and recombinant icSARS-CoV produced similar disease in our macaque model.
Gene_expression (produced) of CoV associated with severe acute respiratory syndrome and disease
3) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1435788 Disease Relevance 2.13 Pain Relevance 0.21
Next to these epithelial cells, the SARS-CoV has also been found in macrophages and many other cells as it has been detected in not only in the respiratory tract and stool specimen but also in the blood, liver, kidney and urine [6].
Gene_expression (found) of CoV in epithelial cells associated with severe acute respiratory syndrome
4) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.26 Pain Relevance 0
Eight recombinant human single-chain variable region fragments (scFvs) against the S1 domain of spike (S) protein of the SARS-CoV from two nonimmune human antibody libraries were screened and one scFv 80R efficiently neutralized SARS-CoV and inhibited syncytia formation between cells expressing the S protein and those expressing the SARS-CoV receptor angiotensin-converting enzyme 2 (ACE2) [117].
Gene_expression (expressing) of CoV in spike associated with severe acute respiratory syndrome
5) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.22 Pain Relevance 0

General Comments

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