INT180743

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 17.94
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SARS) mitochondrion (SARS) RNA binding (SARS)
translation (SARS) ligase activity (SARS) cytoplasm (SARS)
Anatomy Link Frequency
lung 2
respiratory 1
SARS (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 22 99.04 Very High Very High Very High
Inflammation 31 95.40 Very High Very High Very High
corticosteroid 28 89.60 High High
abdominal pain 6 84.00 Quite High
anesthesia 7 75.92 Quite High
Multiple sclerosis 2 71.20 Quite High
headache 14 62.16 Quite High
fibrosis 8 5.24 Low Low
cytokine 21 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 881 100.00 Very High Very High Very High
Infection 304 100.00 Very High Very High Very High
Coronavirus Infection 225 100.00 Very High Very High Very High
Respiratory Failure 29 99.98 Very High Very High Very High
Acute Disease 2 99.56 Very High Very High Very High
Lower Respiratory Tract Infection 38 99.20 Very High Very High Very High
Adult Respiratory Distress Syndrome 63 99.16 Very High Very High Very High
Pressure And Volume Under Development 10 99.14 Very High Very High Very High
Bronchitis 5 98.96 Very High Very High Very High
Disease 179 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although possible, the association of non-SARS HCoV infection and LRTI is uncommon in healthy children.
non-SARS Binding (association) of associated with severe acute respiratory syndrome, lower respiratory tract infection and infection
1) Confidence 0.23 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2957994 Disease Relevance 1.88 Pain Relevance 0.03
Thus, SARS-CoV RNA was found in patients' stool specimen more than 30 days after the infections.


SARS Binding (found) of associated with severe acute respiratory syndrome and infection
2) Confidence 0.22 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 2.40 Pain Relevance 0.06
Whereas the SARS-CoV has been shown to cross-react with some group I coronavirus antibodies [6], its genetic sequence does not belong to this group.
SARS Binding (react) of associated with coronavirus infection and severe acute respiratory syndrome
3) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 2.10 Pain Relevance 0
ACE-2 has a key protective role in acute lung injury by reducing alveolar fluid, and thus the binding of SARS-CoV to ACE-2 may contribute to the dysregulation of fluid balance in the alveolar space [48].
SARS Binding (binding) of in lung associated with severe acute respiratory syndrome and adult respiratory distress syndrome
4) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.01 Pain Relevance 0.10
The similarity between our findings and SARS in children deserves further examination.
SARS Binding (findings) of associated with severe acute respiratory syndrome
5) Confidence 0.19 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1435788 Disease Relevance 2.05 Pain Relevance 0
The same hexapeptidyl chloromethylketone inhibitor used by Anand et al. [85] in their crystallographic study of the TGEV Mpro was employed by Yang et al. [88] to characterize the interaction of the SARS-CoV enzyme with substrate.
SARS Binding (interaction) of associated with severe acute respiratory syndrome
6) Confidence 0.18 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 0.30 Pain Relevance 0
Non-SARS CoV infections have also been associated with acute and chronic CNS diseases (4,20), although no clear evidence has shown that the viruses played a direct causative role.
Non-SARS Binding (associated) of associated with coronavirus infection, severe acute respiratory syndrome, central nervous system, disease and infection
7) Confidence 0.18 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2957994 Disease Relevance 1.82 Pain Relevance 0.21
The binding of SARS-CoV to ACE-2, along with lower levels of MBL, leads to higher viral levels, increased alveolar edema, and the severe acute respiratory failure associated with SARS-CoV.
SARS Binding (associated) of in respiratory associated with pressure and volume under development, severe acute respiratory syndrome and respiratory failure
8) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 1.56 Pain Relevance 0.06
Ritonavir inhibits lopinavir metabolism thus increasing its serum concentration, but it has no activity against SARS-CoV.
SARS Neg (no) Binding (activity) of associated with severe acute respiratory syndrome
9) Confidence 0.15 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074505 Disease Relevance 0.93 Pain Relevance 0.08
A few recent studies implicate a strong association of a novel coronavirus with the worldwide outbreak of SARS (16–18).
SARS Binding (association) of associated with coronavirus infection and severe acute respiratory syndrome
10) Confidence 0.12 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC3016779 Disease Relevance 1.36 Pain Relevance 0
During these simulations we recognized the need for a SARS-specific equipment cart.
SARS Binding (recognized) of associated with severe acute respiratory syndrome
11) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550819 Disease Relevance 1.23 Pain Relevance 0.08
They used an isolated mitochondrial fraction from A549 lung cancer cells incubated with negatively charged 13 nm gold nanoparticles, and studied the interaction with surface-enhanced Raman scattering (SERS).
SERS Binding (interaction) of in lung associated with lung cancer
12) Confidence 0.02 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2946263 Disease Relevance 0.29 Pain Relevance 0

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