INT180752

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 3
Total Number 22
Disease Relevance 9.89
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAFAH1B1) cytosol (PAFAH1B1) transport (PAFAH1B1)
nuclear envelope (PAFAH1B1) nucleolus (PAFAH1B1) nucleus (PAFAH1B1)
PAFAH1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 900 99.20 Very High Very High Very High
Inflammation 20 64.04 Quite High
palliative 2 28.96 Quite Low
Pain 10 18.24 Low Low
abdominal pain 20 5.00 Very Low Very Low Very Low
headache 20 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 32 100.00 Very High Very High Very High
Sprains And Strains 740 99.60 Very High Very High Very High
Leptospirosis 920 99.48 Very High Very High Very High
Hemorrhage 900 99.20 Very High Very High Very High
Disease 320 97.64 Very High Very High Very High
Infection 180 96.44 Very High Very High Very High
Endotoxemia 20 83.04 Quite High
Body Weight 20 82.32 Quite High
Injury 20 78.64 Quite High
Adhesions 20 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The l-paf-ah gene is present unanimously and expressed similarly in either pathogenic or saprophytic leptospires
Gene_expression (expressed) of l-paf-ah gene
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.33 Pain Relevance 0
L. interrogans gene l-paf-ah was synthesized by PCR with strain 56601 or serovar Canicola strain Lin genomic DNAs as the templates (Table 2).
Gene_expression (synthesized) of l-paf-ah associated with sprains and strains
2) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.52 Pain Relevance 0
The results indicated that the l-paf-ah gene is unanimously present in these strains with limited genetic variations.
Gene_expression (present) of l-paf-ah gene associated with sprains and strains
3) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.53 Pain Relevance 0
The heterogeneously expressed L-PAF-AH demonstrated PAF-AH activity similar to that in the human serum
Gene_expression (activity) of PAF-AH
4) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.24 Pain Relevance 0.03
In human, the PAF-AH levels in serum of leptospirosis patients infected by L. interrogans of serogroup Icterohaemorrhagiae were found significantly higher than that of either normal control or patients infected by non-icterohaemorrhagiae leptospires (P<0.01) (Figure 5).
Gene_expression (levels) of PAF-AH associated with leptospirosis
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.66 Pain Relevance 0.08
We determined the PAF-AH levels in the sera of healthy mice (ICR, BALB/c, CBA/N, C57BL/6, DBA/2, and C3H/HeJ), rats (Fischer 344, Sprague-Dawley, and Wistar), golden hamster, guinea pig, Mongolian gerbil, and New Zealand rabbit (Figure 3A).
Spec (determined) Gene_expression (levels) of PAF-AH
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.70 Pain Relevance 0.08
L-PAF-AH contributed little PAF-AH activity to the increase of PAF-AH level in serum in the severe leptospirosis
Gene_expression (activity) of PAF-AH associated with leptospirosis
7) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.76 Pain Relevance 0.15
Implementation of the MDS-HC is complete or underway in 15 states and in 7 Canadian provinces and territories, where it is being used mainly as a clinical assessment instrument.
Gene_expression (Implementation) of MDS associated with myelodysplastic syndromes
8) Confidence 0.65 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC548266 Disease Relevance 0.29 Pain Relevance 0
In Ontario, it is now mandatory for all long stay home care clients to be assessed with the MDS-HC.
Gene_expression (assessed) of MDS associated with myelodysplastic syndromes
9) Confidence 0.65 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC548266 Disease Relevance 0.41 Pain Relevance 0
The L-PAF-AH was proven to be an intracellular protein, which was encoded unanimously and expressed similarly in either pathogenic or saprophytic leptospires.
Gene_expression (expressed) of L-PAF-AH
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2615213 Disease Relevance 0.62 Pain Relevance 0.15
The l-paf-ah gene, with its original 66 nucleotides deleted from 5?
Gene_expression (with) of l-paf-ah gene
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.18 Pain Relevance 0.03
The l-paf-ah gene is present unanimously and expressed similarly in either pathogenic or saprophytic leptospires
Gene_expression (expressed) of l-paf-ah gene
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.33 Pain Relevance 0
Meanwhile, the Km of the human serum PAF-AH towards the artificial substrate was found to be 0.27 mM assayed by the same methodology (Table 1), which is in the same order of magnitude with that of the rL-PAF-AH (0.61 mM).


Gene_expression (found) of serum PAF-AH
13) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.06 Pain Relevance 0
Although, so far, there is no complete data available for enzyme kinetic parameters of the serum PAF-AH towards this artificial substrate, its Km was determined in this study, which is similar to that of the L-PAF-AH.
Gene_expression (parameters) of serum PAF-AH
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.20 Pain Relevance 0.03
The present study first investigated the serum PAF-AH levels of the commonly used experimental rodent and rabbit species, particularly guinea pig [13], [31], [32] and golden hamster [33], the most common models for the leptospirosis studies and found that only Mongolian gerbil has its normal serum PAF-AH level similar to that of human (Figure 3A).
Gene_expression (level) of serum PAF-AH associated with leptospirosis
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.87 Pain Relevance 0.03
The assay indicated that L-PAF-AH in the media was not detected until entering the early-stationary phase (103 hr) when bacterial cell lysis was observed (Figure 2).
Neg (not) Gene_expression (detected) of L-PAF-AH
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.30 Pain Relevance 0
The present study first investigated the serum PAF-AH levels of the commonly used experimental rodent and rabbit species, particularly guinea pig [13], [31], [32] and golden hamster [33], the most common models for the leptospirosis studies and found that only Mongolian gerbil has its normal serum PAF-AH level similar to that of human (Figure 3A).
Spec (investigated) Gene_expression (levels) of serum PAF-AH associated with leptospirosis
17) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.77 Pain Relevance 0.03
The heterogeneously expressed L-PAF-AH demonstrated PAF-AH activity similar to that in the human serum
Gene_expression (expressed) of L-PAF-AH
18) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.25 Pain Relevance 0.03
There was only one asynonymou single nucleotide variation (SNV) causing the Y195H amino acid switch (Table 2) found in the l-paf-ah gene out of maximal 8 SNVs from four leptospires (Figure S2).
Gene_expression (found) of l-paf-ah gene
19) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.54 Pain Relevance 0
Production of anti-L-PAF-AH rabbit polyclonal serum and murine monoclonal antibodies (MoAbs)
Gene_expression (Production) of anti-L-PAF-AH
20) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0 Pain Relevance 0

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