INT180774

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.43
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) cell proliferation (Gdnf) extracellular space (Gdnf)
extracellular region (Gdnf) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 1
Gdnf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 480 100.00 Very High Very High Very High
Nerve growth factor 500 99.90 Very High Very High Very High
trigeminal ganglion 295 98.92 Very High Very High Very High
qutenza 260 98.28 Very High Very High Very High
Inflammation 30 89.84 High High
Neuropeptide 55 88.80 High High
dorsal root ganglion 60 50.72 Quite High
Trigeminal ganglion neurons 5 50.00 Quite Low
agonist 30 39.52 Quite Low
Cannabinoid 10 38.76 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 365 98.92 Very High Very High Very High
INFLAMMATION 25 89.84 High High
Nociception 40 74.56 Quite High
Headache 30 29.56 Quite Low
Disease 10 26.24 Quite Low
Hyperalgesia 35 21.60 Low Low
Injury 115 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Nervous System Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF and GDNF (100 ng/ml) each was demonstrated to have increased TRPV1 protein levels by approximately 50% compared with no growth factor-treated cultures (Fig 5).
GDNF Positive_regulation (increased) of TRPV1 protein associated with nerve growth factor
1) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.14 Pain Relevance 0.63
NGF and GDNF each increased TRPV1 protein, and both upregulated the CGRP content of TG neurons.
GDNF Positive_regulation (increased) of TRPV1 protein in neurons associated with nerve growth factor, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.27 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.70 Pain Relevance 0.77
Interestingly, the study by Bron et al. (2003) indicated that GDNF is also able to upregulate TRPV1 expression; although this conclusion was based on immunofluorescence and cobalt uptake assays, it is consistent with our direct demonstration of GDNF-induced upregulation of TRPV1 protein by Western blot.
GDNF-induced Positive_regulation (upregulation) of TRPV1 protein
3) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.39 Pain Relevance 0.92
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
GDNF Positive_regulation (increasing) of TRPV1 protein associated with nerve growth factor and calcitonin gene-related peptide
4) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.62 Pain Relevance 1.35
Both the NGF- and GDNF-induced upregulation of TRPV1 appears to be translationally regulated, as neither of these growth factors altered TRPV1 mRNA levels.
GDNF-induced Positive_regulation (upregulation) of TRPV1 associated with nerve growth factor
5) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.58 Pain Relevance 0.71

General Comments

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