INT180785

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.96
Pain Relevance 8.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gdnf, Calca) extracellular region (Gdnf, Calca) cell proliferation (Gdnf)
aging (Calca) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
neurons 3
Gdnf (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 800 100.00 Very High Very High Very High
Calcitonin gene-related peptide 768 100.00 Very High Very High Very High
trigeminal ganglion 472 100.00 Very High Very High Very High
qutenza 416 100.00 Very High Very High Very High
agonist 48 96.88 Very High Very High Very High
Cannabinoid 16 96.12 Very High Very High Very High
neuropeptide release 24 92.64 High High
Neuropeptide 88 88.80 High High
Inflammation 48 80.88 Quite High
Hyperalgesia 24 79.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 584 100.00 Very High Very High Very High
INFLAMMATION 40 80.88 Quite High
Hyperalgesia 56 79.44 Quite High
Nociception 64 72.08 Quite High
Pain 24 60.08 Quite High
Injury 184 46.24 Quite Low
Headache 48 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Nervous System Injury 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
GDNF Positive_regulation (increased) of CGRP release associated with nerve growth factor and calcitonin gene-related peptide
1) Confidence 0.23 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.84
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
GDNF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
2) Confidence 0.23 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.83
Both NGF and GDNF increased CGRP content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).
GDNF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
3) Confidence 0.23 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.80
As in the case with CAP, the effects of AEA and ACEA on evoked CGRP release were augmented by supplementation of TG cultures with NGF (Fig. 10A) or GDNF (Fig. 10B).
GDNF Positive_regulation (augmented) of CGRP release associated with nerve growth factor, qutenza, trigeminal ganglion and calcitonin gene-related peptide
4) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.28 Pain Relevance 1.36
We have also illustrated that chronic application of NGF or GDNF, but not BDNF (except at high concentrations, and to a much lesser degree), increases CAP-evoked CGRP release from TG neurons in vitro.
GDNF Positive_regulation (increases) of CGRP release in neurons associated with qutenza, nerve growth factor, trigeminal ganglion and calcitonin gene-related peptide
5) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.77 Pain Relevance 0.80
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
GDNF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
6) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.61 Pain Relevance 1.34
Interestingly, the GDNF augmentation of CGRP release appeared to be due primarily to the large increases in neuron survival, because only the 10 ng/ml GDNF condition was significantly greater than control (p < 0.001), but still substantial lower compared with the untransformed lysis figures (Fig. 6D).
GDNF Positive_regulation (augmentation) of CGRP release in neuron associated with calcitonin gene-related peptide
7) Confidence 0.19 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.92
On the other hand, GDNF appears to increase the responsiveness of the in vitro population by altering the proportion of TRPV1 neurons and upregulating the releasable pool of CGRP, as evidenced by the persistent increase in 50 mM K+-evoked CGRP release after normalization.
GDNF Positive_regulation (upregulating) of CGRP in neurons associated with calcitonin gene-related peptide
8) Confidence 0.19 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.30 Pain Relevance 1.15

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